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Natural blood plasma-based hydrogels as tumor vaccines delivery systems to enhance biomimetic recruitment of antigen presenting cells for tumor immunotherapy

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成果类型:
期刊论文
作者:
Huang, Linghong;Peng, Sufen;Liu, Zonghua;Zhang, Juncheng;Liu, Ning;...
通讯作者:
Ning Liu<&wdkj&>Jiansheng Lin
作者机构:
[Huang, Linghong; Liu, Zonghua; Peng, Sufen] Jinan Univ, Dept Biomed Engn, Guangzhou 510632, Peoples R China.
[Liu, Ning; Zhang, Juncheng] Jinan Univ, Dept Bone & Joint Surg, Affiliated Hosp 1, Guangzhou 510632, Peoples R China.
[Lin, Jiansheng] Hunan Univ Chinese Med, Dept Anat, Changsha 410208, Peoples R China.
通讯机构:
[Ning Liu; Jiansheng Lin] D
Department of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China<&wdkj&>Department of Anatomy, Hunan University of Chinese Medicine, Changsha, 410208, China
语种:
英文
关键词:
Tumor immunotherapy;Tumor vaccines;Blood plasma hydrogel;APCs recruitment
期刊:
Materials Today Bio
ISSN:
2590-0064
年:
2022
卷:
17
页码:
100497
基金类别:
Science and Technology Program of Guangzhou, China [202103030004]; Research Fund of Hunan University of Traditional Chinese Medicine, China [2020XJJJ013]; National Natural Science Foundation of China [81904060]; Excellent Youth Project of Education Department of Hunan Province [21B0367]
机构署名:
本校为通讯机构
院系归属:
中医学院
摘要:
Tumor vaccines can inhibit or eliminate tumors by vaccinating hosts with tumor antigens to activate antigen-specific immune responses and have gained wild attention. However, their clinical application efficacy is often comprised due to the low safety and poor efficiency of vaccine adjuvants/carriers. Specifically, the adjuvants/carriers usually could not efficiently recruit antigen presenting cells (APCs) to capture the vaccines or directly damage these cells. Therefore, ideal tumor vaccine adjuvants/carriers should effectively recruit APCs and be friendly to the cells for well keeping their ...

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