期刊论文

Effect of Buyang Huanwu Decoction on Cerebral NF-κB/p50 Expression of Rats with Focal Cerebral Ischemia Injury

中文

中医药信息

1002-2406

2014

4

98-101

国家自然科学基金资助项目（No.81072939） 国家自然科学基金资助项目（No.81302953） 湖南省教育厅项目（No.13B082）

本校为第一机构

目的：探讨补阳还五汤对脑缺血后大鼠脑组织NF-κB/p50表达的影响。方法：将180只SD大鼠随机分为空白组、假手术组、模型组、补阳还五汤组、PDTC（呲咯烷二硫代氨基甲酸盐）组和米诺环素组，各30只，每组按给药后7天、14天、21天3个时间点再各分为3个亚组，观察各组不同时间点的神经功能评分，免疫组化检测缺血脑组织NF-κB/p50蛋白表达情况。结果：补阳还五汤组、米诺环素组、PDTC组各时间点神经功能缺失症状评分和脑组织NF-κB/p50阳性细胞数与模型组比较，均明显减少（P＜0．05或P＜0．01）；用药7天、14天后，补阳还五汤组NF-κB/p50阳性细胞数与米诺环素组，PDTC组组间差异无统计学意义（P...

Objective:To observe the effect of Buyang Huanwu decoction on NF -κB/p50 expression in brain tissue of rats with focal cerebral ischemia injury .Methods:One hundred and eighty SD rats were randomly di-vided into normal group , Sham -operated group , ischemia group , BYHWD treatment group , PDTC treatment group and MC treatment group .Each group was divided into three subgroups according to the time after admin-istration for 7d,14d,21d respectively.Neurological function score and NF -κB/p50 protein levels were exam-ined by using immunohistoche...