Quercetin improves contrast-induced acute kidney injury through the HIF-1 alpha/lncRNA NEAT1/HMGB1 pathway

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成果类型：

期刊论文

作者：

Luo, Min;Liu, Ziyu;Hu, Zongren;He, Qinghu

通讯作者：

Min Luo<&wdkj&>Qinghu He

作者机构：

[Luo, Min] Cent South Univ, Xiangya Hosp 2, Dept Nephrol, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.

[Luo, Min; Hu, Zongren; He, Qinghu] Hunan Univ Med, Dept Rehabil Med & Hlth Care, Huaihua 418000, Hunan, Peoples R China.

[Luo, Min; Hu, Zongren; He, Qinghu] Hunan Univ Chinese Med, Coll Tradit Chinese Med, Changsha, Hunan, Peoples R China.

[Liu, Ziyu] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Min Luo; Qinghu He] D

Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China<&wdkj&>Department of Rehabilitation Medicine and Health Care, Hunan University of Medicine, Huaihua, Hunan Province, China<&wdkj&>College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan Province, China<&wdkj&>Department of Rehabilitation Medicine and Health Care, Hunan University of Medicine, Huaihua, Hunan Province, China<&wdkj&>College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan Province, China

语种：

英文

关键词：

CI-AKI cell model;HuangKui;cell injury and apoptosis;NEAT1

期刊：

Pharmaceutical Biology

ISSN：

1388-0209

年：

2022

卷：

期：

页码：

889-898

DOI：

10.1080/13880209.2022.2058558

基金类别：

This work was supported by National Natural Science Foundation of China (No.81804079) and Natural Science Foundation of Hunan Province (No.2017JJ3442).

机构署名：

本校为其他机构

院系归属：

中医学院

中西医结合学院

摘要：

Context: The risk of contrast-induced acute kidney injury (CI-AKI) is increasing and the harm is great. Quercetin is the main active component in Abelmoschus manihot (L.) Medik (Malvaceae) and was reported to reduce the expression of HIF-1α. Objective: We investigate whether quercetin improves the CI-AKI through the HIF-1α/lncRNA NEAT1/HMGB1 pathway. Materials and methods: HK-2 cells were treated with iohexol (200 mg/mL) for 6 h to establish a CI-AKI model. Quercetin (20 μM) was administered to CI-AKI cells cultured in dishes for 24 h. Cell ...

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Quercetin improves contrast-induced acute kidney injury through the HIF-1 alpha/lncRNA NEAT1/HMGB1 pathway

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