Combining Oxymatrine or Matrine with Lamivudine Increased Its Antireplication Effect against the Hepatitis B Virus In Vitro

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成果类型：

期刊论文

作者：

Ma, Zhi-Jie;Li, Qi;Wang, Jia-Bo*;Zhao, Yan-Ling;Zhong, Yan-Wei;...

通讯作者：

Wang, Jia-Bo

作者机构：

[Ma, Zhi-Jie; Pu, Shi-Biao; Li, Qi; Liu, Fei-Fei; Zeng, Ling-Na; Wang, Jia-Bo; Zhao, Yan-Ling] 302 Mil Hosp, China Mil Inst Chinese Med, Beijing 100039, Peoples R China.

[Ma, Zhi-Jie] Chengdu Univ Tradit Chinese Med, Coll Tradit Chinese Med, Chengdu 610075, Sichnan, Peoples R China.

[Zhong, Yan-Wei] 302 Mil Hosp, Pediat Liver Dis erapy & Res Ctr, Beijing 100039, Peoples R China.

[Yang, Hui-Yin; Wang, Rui-Lin; Xiao, Xiao-He; Bai, Yun-Feng; Li, Jian-Yu] 302 Mil Hosp, Integrat Med Ctr, Beijing 100039, Peoples R China.

[Xiao, Da-Ke] China Pharmaceut Univ, Coll Pharm, Nanjing 211198, Jiangsu, Peoples R China.

通讯机构：

[Wang, Jia-Bo] 3

302 Mil Hosp, China Mil Inst Chinese Med, Beijing 100039, Peoples R China.

语种：

英文

期刊：

Evidence-Based Complementary and Alternative Medicine

ISSN：

1741-427X

年：

2013

卷：

2013

页码：

186573

DOI：

10.1155/2013/186573

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30973947, 81274026, 81173571]; National Industry Program of China [200807020, 201207002]; National Key Technology RD ProgramNational Key Technology R&D Program [2012BAI29B02, 2012ZX10005010-002-002]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Some recent clinical reports have shown that the combination of oxymatrine, a phyto-derived drug, with lamivudine (3TC) could improve its curative effect against hepatitis B virus (HBV) infection. However, the experimental data in support of this combination strategy are lacking. In this study, we investigated the anti-HBV activity of the combination of 3TC and either oxymatrine or matrine on HepG2 2.2.15 in vitro. The activities of the combination and the solo compound, each in different concentrations, were compared on the 3rd, 6th, and 9th e...

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Combining Oxymatrine or Matrine with Lamivudine Increased Its Antireplication Effect against the Hepatitis B Virus In Vitro

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