期刊论文

Effects of Zhuanggu Zhitong Formula on thesignal system of Wnt/β-catenin and RANKL/RANK/OPG in rates with osteoporosis

中文

北京中医药

1674-1307

2017

36

7

611-613

10.16025/j.1674-1307.2017.07.008

陕西省教育厅自然专项计划基金项目（15JK1212）；

本校为其他机构

目的探讨壮骨止痛方对骨质疏松雌鼠Wnt/β-链蛋白（Wnt/β-catenin）、核因子κB受体活化因子配体/核因子κB受体活化因子/骨保护蛋白（RANKL/RANK/OPG）信号通路的影响。方法将大鼠分为假手术组、模型组、壮骨止痛方高剂量组、壮骨止痛方低剂量组、雌二醇组,用酶联免疫法测定大鼠血清中β-catenin、OPG、RANKL的水平。结果模型组大鼠血清β-catenin明显降低,RANKL/OPG比值升高,经壮骨止痛方药物干预后,β-catenin水平明显升高,RANKL/OPG比值明显下降。结论壮骨止痛方可能通过提升大鼠血清β-catenin的含量,降低RANKL/OPG的比值,从而激活Wnt/β-catenin、RANKL/RANK/OPG信号通路,起到防治骨质疏...

Objective To explore the effects of Zhuanggu Zhitong Formula on Wnt/beta-catenin and RANKL/RANK/OPG signal system in female rats with osteoporosis.Methods The rats were divided into the sham group,model group,Zhuanggu Zhitong Formula high dose group,Zhuanggu Zhitong Formula low dose group,and estradiol group.The level of β-catenin,OPG and RANGKL in rat serum were determined by ELISA.Results The serum β-catenin of model group was reduced and the ratio of RANKL/OPG level rise,but after the intervention by Zhuanggu Zhitong Formula,β-catenin lev...