Anti-inflammatory effects of two lupane-type triterpenes from leaves of Acanthopanax gracilistylus on LPS-induced RAW264.7 macrophages

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成果类型：

期刊论文

作者：

Luo, Jiao;Li, Xiao-jun;Lee, Geon-ho;Huang, Jian-jun;Whang, Wan-kyunn;...

通讯作者：

Liu, X.-Q.

作者机构：

[Li, Xiao-jun; Liu, Xiang-qian; Luo, Jiao] Hunan Univ Chinese Med, Sch Pharm, Changsha, Peoples R China.

[Li, Xiao-jun] Gannan Med Univ, Coll Pharmaceut Sci, Ganzhou, Jiangxi, Peoples R China.

[Lee, Geon-ho] Kwanak Goo, Kyunghee Korean Pharm, Seoul, South Korea.

[Huang, Jian-jun] Cent South Univ, Xiangya Med Coll, Dept Clin Biochem, Changsha, Peoples R China.

[Whang, Wan-kyunn] Chung Ang Univ, Coll Pharm, Seoul, South Korea.

通讯机构：

School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China

语种：

英文

关键词：

Acanthopanax gracilistylus WW Smith;lupane-type triterpenes;RAW 264.7 macrophages;proinflammatory cytokines;HMGB1;NF-kappa B

期刊：

Food Science and Technology

ISSN：

0101-2061

年：

2022

卷：

DOI：

10.1590/fst.89721

基金类别：

Natural Science Foundation of Hunan Province, China [2019JJ40223]; Doctoral Scientific Research Starting Foundation of Gannan Medical University [QD201905]

机构署名：

本校为第一机构

院系归属：

药学院

摘要：

Acanthopanax gracilistylus W.W.Smith (AGS) is an traditional Chinese medicine and its leaves that have rich biological activities has been long used as a fresh vegetable in Chinese folk. There are two lupane-type triterpenoids, 3α,11α-dihydroxy-23-oxo-lup-20(29)-en-28-oic acid (1) and 3α,11α,23-trihydroxy-lup-20(29)-en-28-oic acid (2), were isolated as the active constituents from leaves of AGS. However, the anti-inflammatory effects and potential mechanisms of 1 and 2 on LPS-induced RAW264.7 Macrophages have not been evaluated. In this stu...

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Anti-inflammatory effects of two lupane-type triterpenes from leaves of Acanthopanax gracilistylus on LPS-induced RAW264.7 macrophages

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