Renin-angiotensin system promotes colonic inflammation by inducing TH17 activation via JAK2/STAT pathway.

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成果类型：

期刊论文

作者：

He, Lei;Du, Jie;Chen, Yinyin;Liu, Chunyan;Zhou, Min;...

通讯作者：

Li, YC

作者机构：

[Adhikari, Sarbani; Pekow, Joel; Rubin, David T.; Zhou, Min; He, Lei; Du, Jie; Chen, Yinyin; Liu, Chunyan; Li, Yan Chun] Univ Chicago, Dept Med, Div Biol Sci, Chicago, IL 60637 USA.

[Du, Jie] Shanxi Med Univ, Inst Biomed Res, Taiyuan, Shanxi, Peoples R China.

[Chen, Yinyin] Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Nephrol, Changsha, Hunan, Peoples R China.

[Liu, Chunyan] Hunan Univ Chinese Med, Dept Pathol, Changsha, Hunan, Peoples R China.

[Zhou, Min] Shanghai Jiao Tong Univ, Xinhua Hosp, Div Gastroenterol, Sch Med, Shanghai, Peoples R China.

通讯机构：

[Li, YC ] U

Univ Chicago, Dept Med, 900 E 57th St,KCBD 9110, Chicago, IL 60637 USA.

语种：

英文

关键词：

JAK;STAT;T17;colitis;mucosal inflammation;renin-angiotensin system

期刊：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

ISSN：

0193-1857

年：

2019

卷：

316

期：

页码：

G774-G784

DOI：

10.1152/ajpgi.00053.2019

基金类别：

Y. C. Li obtained a research grant from Pfizer Co. to support this research. Other authors have declared that no conflict of interest exists in this work.

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Previous studies suggest that the renin-angiotensin system (RAS) is a pathogenic factor for colitis. The goal of this study was to elucidate the molecular mechanism whereby angiotensin II (ANG II) promotes colonic inflammation. We found that renin was highly induced in colonic biopsies from patients with ulcerative colitis or Crohn's disease, and colonic renin and ANG II levels were markedly increased in a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model, indicating that the colonic RAS is activated in colitis. Renin transgenic (RenTg) mice exhibited increased phosphorylation i...

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Renin-angiotensin system promotes colonic inflammation by inducing TH17 activation via JAK2/STAT pathway.

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