Studies on the cytotoxicity and anticancer performance of heterocyclic hypervalent organobismuth(III) compounds

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成果类型：

期刊论文

作者：

Liu, Yong-Ping（刘永平）;Lei, Jian;Tang, Li-Wen;Peng, Yao;Au, Chak-Tong;...

通讯作者：

Chen, Y;Yin, SF

作者机构：

[Liu, Yong-Ping; Chen, Yi; Chen, Y] Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.

[Chen, Yi; Peng, Yao; Lei, Jian; Yin, Shuang-Feng; Yin, SF] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

[Tang, Li-Wen] Hunan Univ Chinese Med, Dept Oncol, Hosp 1, Changsha 410208, Hunan, Peoples R China.

[Au, Chak-Tong] Hunan Inst Engn, Coll Chem & Chem Engn, Xiangtan 411104, Peoples R China.

通讯机构：

[Chen, Y ; Yin, SF ] H

Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.

Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Cancerous cells;Cytotoxicity;Organobismuth(III)

期刊：

European Journal of Medicinal Chemistry

ISSN：

0223-5234

年：

2017

卷：

139

页码：

826-835

DOI：

10.1016/j.ejmech.2017.08.043

基金类别：

This work was supported by the National Natural Science Foundation of China (21571060), and the Natural Science Foundation of Hunan Province (10JJ1003); CTA thanks HNU for an adjunct professorship.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

第一中医临床学院

摘要：

Novel organobismuth(III) complex of 5H-dibenzo[c,f][1,5]oxabismocin-12(7H)-yl nitrate (C2) was synthesized and characterized by spectral and elemental analysis. It was compared with other five C,E,C-chelating (E = N, O, S) organobismuth(III) complexes against human adenocarcinoma alveolar basal epithelial cells (A549), human liver cancer cell line (SMCC7721), human gastric cancer cell line (SGC-7901), human colon adenocarcinoma cell line (SW480) and healthy human bronchial cell line (16HBE14o-) in vitro. It was found that C2 exhibited the best anticancer activity. Further mechanistic investiga...

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Studies on the cytotoxicity and anticancer performance of heterocyclic hypervalent organobismuth(III) compounds

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