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Studies on the cytotoxicity and anticancer performance of heterocyclic hypervalent organobismuth(III) compounds

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成果类型:
期刊论文
作者:
Liu, Yong-Ping(刘永平);Lei, Jian;Tang, Li-Wen;Peng, Yao;Au, Chak-Tong;...
通讯作者:
Chen, Yi(陈懿);Yin, Shuang-Feng
作者机构:
[Liu, Yong-Ping; Chen, Yi] Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.
[Chen, Yi; Peng, Yao; Lei, Jian; Yin, Shuang-Feng] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.
[Tang, Li-Wen] Hunan Univ Chinese Med, Dept Oncol, Hosp 1, Changsha 410208, Hunan, Peoples R China.
[Au, Chak-Tong] Hunan Inst Engn, Coll Chem & Chem Engn, Xiangtan 411104, Peoples R China.
通讯机构:
[Chen, Yi; Yin, Shuang-Feng] H
Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.
Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.
语种:
英文
关键词:
Organobismuth(III);Cytotoxicity;Cancerous cells;Apoptosis
期刊:
European Journal of Medicinal Chemistry
ISSN:
0223-5234
年:
2017
卷:
139
页码:
826-835
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21571060]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [10JJ1003]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
第一中医临床学院
摘要:
Novel organobismuth(III) complex of 5H-dibenzo[c,f][1,5]oxabismocin-12(7H)-yl nitrate (C2) was synthesized and characterized by spectral and elemental analysis. It was compared with other five C,E,C-chelating (E = N, O, S) organobismuth(III) complexes against human adenocarcinoma alveolar basal epithelial cells (A549), human liver cancer cell line (SMCC7721), human gastric cancer cell line (SGC-7901), human colon adenocarcinoma cell line (SW480) and healthy human bronchial cell line (16HBE14o-) in vitro. It was found that C2 exhibited the best anticancer activity. Further mechanistic investiga...

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