Rubrofusarin-6-β-gentiobioside inhibits lipid accumulation and weight gain by regulating AMPK/mTOR signaling

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成果类型：

期刊论文

作者：

Han, Yo-Han;Kee, Ji-Ye;Park, Seong-Hwan;Mun, Jeong-Geon;Jeon, Hee-Dong;...

通讯作者：

Hong, Seung-Heon

作者机构：

[Kee, Ji-Ye; Jeon, Hee-Dong; Hong, Seung-Heon; Mun, Jeong-Geon; Han, Yo-Han; Park, Seong-Hwan] Wonkwang Univ, Wonkwang Oriental Med Res Inst, Coll Pharm, Dept Oriental Pharm, 460 Iksandae Ro, Iksan 54538, Jeonbuk, South Korea.

[Park, Seong-Hwan] Korea Inst Oriental Med, Clin Med Div, Daejeon, South Korea.

[Park, Jinbong] Kyung Hee Univ, Coll Korean Med, Dept Pharmacol, 26 Kyungheedae Ro, Seoul 02447, South Korea.

[Zou, Qin-Peng] Changsha Broad Ocean Biosci & Tech Co Ltd, Changsha 410205, Hunan, Peoples R China.

[Liu, Xiang-Qian] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Hong, Seung-Heon] W

Wonkwang Univ, Wonkwang Oriental Med Res Inst, Coll Pharm, Dept Oriental Pharm, 460 Iksandae Ro, Iksan 54538, Jeonbuk, South Korea.

语种：

英文

关键词：

3T3-L1;AMPK;Cassiae tora seed;Human adipose mesenchymal stem cells;Rubrofusarin-6-beta-gentiobioside;mTOR

期刊：

Phytomedicine

ISSN：

0944-7113

年：

2019

卷：

页码：

152952

DOI：

10.1016/j.phymed.2019.152952

基金类别：

National Research Foundation of Korea (NRF) - Korean government (MSIT) [NRF-2016R1A2B2013921, 2018R1D1A3B07040871, 2018R1C1B6002722]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

BACKGROUND: Although rubrofusarin-6-beta-gentiobioside (RFG), which is a component of Cassiae tora seed, could likely regulate hyperlipidemia, its anti-obesity effect and related mechanism have not been elucidated. PURPOSE: The aim of this study was to examine whether RFG can ameliorate obesity and the mechanism of lipid accumulation regulated by RFG. STUDY DESIGN: In in vitro experiments, we confirmed the anti-adipogenic effect of RFG using 3T3-L1 cells and human adipose mesenchymal stem cells (hAMSCs). To confirm the anti-obesity effect, High-Fat Diet (HFD)-induced obese mice were selected a...

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Rubrofusarin-6-β-gentiobioside inhibits lipid accumulation and weight gain by regulating AMPK/mTOR signaling

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