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Inflammatory Milieu Related to Dysbiotic Gut Microbiota Promotes Tumorigenesis of Hepatocellular Carcinoma

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成果类型:
期刊论文
作者:
Huang, Caizhi;Mei, Si;Zhang, Xue;Tian, Xuefei
通讯作者:
Tian, XF
作者机构:
[Huang, Caizhi; Tian, Xuefei; Tian, XF] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Dept Internal Med, Changsha, Peoples R China.
[Huang, Caizhi] Hunan Childrens Hosp, Dept Lab Med, Changsha, Peoples R China.
[Mei, Si] Hunan Univ Chinese Med, Dept Physiol, Changsha, Peoples R China.
[Zhang, Xue] Hunan Univ Chinese Med, Key Lab Tradit Chinese Med Mech Tumor Prevent & Tr, Changsha, Peoples R China.
[Tian, Xuefei; Tian, XF] Hunan Univ Chinese Med, Hunan Prov Univ, Key Lab Oncol Tradit Chinese Med, Changsha, Hunan, Peoples R China.
通讯机构:
[Tian, XF ] H
Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Dept Internal Med, Changsha, Peoples R China.
Hunan Univ Chinese Med, Hunan Prov Univ, Key Lab Oncol Tradit Chinese Med, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
gut microbiota, hepatocellular carcinoma, inflammation, dysbiosis
期刊:
Journal of Clinical Gastroenterology
ISSN:
0192-0790
年:
2023
卷:
57
期:
8
页码:
782-788
基金类别:
National Natural Science Foundation of China [82074450]; key scientific research project of Hunan Education Department [21A0243]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
中西医结合学院
摘要:
Hepatocellular carcinoma (HCC) is an invasive primary liver cancer caused by multiple pathogenic factors and is a significant global health concern. With few effective therapeutic options, HCC is a heterogeneous carcinoma that typically arises in an inflammatory environment. Recent studies have suggested that dysbiotic gut microbiota is involved in hepatocarcinogenesis via multiple mechanisms. In this review, we discuss the effects of gut microbiota, microbial components, and microbiota-derived metabolites on the promotion and progression of HCC by feeding a persistent inflammatory milieu. In ...

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