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Resolving neuroinflammation, the therapeutic potential of the anti-malaria drug family of artemisinin

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成果类型:
期刊论文
作者:
Shi, Zhe;Chen, Ying;Lu, Cong;Dong, Li-ming;Lv, Jing-wei;...
通讯作者:
Liao, Duan-fang;Liu, XM;Zhu, XX
作者机构:
[Qin, Li; Liu, Xin-min; Liao, Duan-fang; Tuo, Qin-hui; Shi, Zhe; Liao, DF] Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.
[Chen, Ying; Lin, Na; Zhu, Xiao-xin] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
[Lu, Cong; Liu, Xin-min; Dong, Li-ming; Lv, Jing-wei] Chinese Acad Med Sci, Inst Med Plant Dev IMPLAD, Res Ctr Pharmacol & Toxicol, Beijing 100193, Peoples R China.
[Lu, Cong; Liu, Xin-min; Dong, Li-ming; Lv, Jing-wei] Peking Union Med Coll, Beijing 100193, Peoples R China.
[Bu, Lan-lan; Tuo, Qin-hui] Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Zhu, XX ] C
[Liu, XM ; Liao, DF] H
Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.
China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
Chinese Acad Med Sci, Inst Med Plant Dev IMPLAD, Res Ctr Pharmacol & Toxicol, Beijing 100193, Peoples R China.
语种:
英文
关键词:
amyloid beta protein;artemisinin;antiinflammatory agent;antimalarial agent;artemisinin derivative;neuroprotective agent;Alzheimer disease;antiinflammatory activity;blood brain barrier;brain protection;cell protection;glia cell;human;nervous system inflammation;neuroprotection;neurotoxicity;nonhuman;oxidative stress;priority journal;Review;signal transduction;structure activity relation;treatment response;Alzheimer disease;animal;central nervous system;drug effect;intestine;Alzheimer Disease;Animals;Anti-Inflammatory Agents;Antimalarials;Artemisinins;Central Nervous System;Humans;Intestines;Neuroprotective Agents
期刊:
Pharmacological Research
ISSN:
1043-6618
年:
2018
卷:
136
页码:
172-180
基金类别:
This work was supported by Major new drug creation Foundation of China (No. 2017ZX09101002-002-008 ), National Natural Science Foundation of China ( 31371161 , 81670268 , 81773930 ), CAMS Initiative for Innovative Medicine ( 2016-I2M-2-006 ) and Scientific Research Fund of Hunan Provincial Education ( 15C1031 ).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学院
摘要:
Artemisinin (Qinghaosu) and its semi-synthetic derivatives have been demonstrated to alleviate neuroinflammatory response in the central nerve system (CNS). In this review, we summarized that artemisinins are capable to treat neuroinflammtion-related CNS diseases in both direct (via regulating inflammatory process in the CNS, exerting anti-oxidative stress and neuroprotective effect, and preventing Aβ accumulation) and indirect (via maintaining BBB integrity, suppressing systemic inflammation and alleviating intestinal inflammtion) manner. How...

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