Resolving neuroinflammation, the therapeutic potential of the anti-malaria drug family of artemisinin

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Shi, Zhe;Chen, Ying;Lu, Cong;Dong, Li-ming;Lv, Jing-wei;...

通讯作者：

Liao, Duan-fang;Liu, Xin-min;Zhu, Xiao-xin

作者机构：

[Liao, DF; Liu, Xin-min; Qin, Li; Liao, Duan-fang; Tuo, Qin-hui; Shi, Zhe] Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

[Chen, Ying; Lin, Na; Zhu, Xiao-xin] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.

[Lu, Cong; Liu, Xin-min; Dong, Li-ming; Lv, Jing-wei] Chinese Acad Med Sci, Inst Med Plant Dev IMPLAD, Res Ctr Pharmacol & Toxicol, Beijing 100193, Peoples R China.

[Lu, Cong; Liu, Xin-min; Dong, Li-ming; Lv, Jing-wei] Peking Union Med Coll, Beijing 100193, Peoples R China.

[Bu, Lan-lan; Tuo, Qin-hui] Hunan Univ Chinese Med, Sch Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Liao, DF; Liu, XM] H

[Zhu, Xiao-xin; Liu, Xin-min] C

[Liu, Xin-min] P

Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.

语种：

英文

关键词：

Artemisinins;Endoperoxide bridge;Neuroinflammtion;Neurotoxicity;CNS disease

期刊：

Pharmacological Research

ISSN：

1043-6618

年：

2018

卷：

136

页码：

172-180

DOI：

10.1016/j.phrs.2018.09.002

基金类别：

Major new drug creation Foundation of China [2017ZX09101002-002-008]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31371161, 81670268, 81773930]; CAMS Initiative for Innovative Medicine [2016-I2M-2-006]; Scientific Research Fund of Hunan Provincial Education [15C1031]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学院

摘要：

Artemisinin (Qinghaosu) and its semi-synthetic derivatives have been demonstrated to alleviate neuroinflammatory response in the central nerve system (CNS). In this review, we summarized that artemisinins are capable to treat neuroinflammtion-related CNS diseases in both direct (via regulating inflammatory process in the CNS, exerting anti-oxidative stress and neuroprotective effect, and preventing Aβ accumulation) and indirect (via maintaining BBB integrity, suppressing systemic inflammation and alleviating intestinal inflammtion) manner. How...

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Resolving neuroinflammation, the therapeutic potential of the anti-malaria drug family of artemisinin

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