期刊论文

中文

中国中医急症

1004-745X

2015

24

8

1327-1329

10.3969/j.issn.1004-745X.2015.08.005

湖南省科技厅科技项目（2013SK3214）；

本校为第一机构

目的观察桃叶珊瑚苷对急性脑出血大鼠血肿周围组织白介素-1β（IL-1β）及核转录因子-κB（NF-κB）表达的影响,探讨桃叶珊瑚苷保护脑出血后神经元损伤的机制。方法健康SD大鼠90只按随机数字表法随机分为假手术组、脑出血组、桃叶珊瑚苷组。脑出血组及桃叶珊瑚苷组于大鼠尾壳核区注入自体非肝素抗凝动脉血,建立脑出血动物模型,假手术组于相同部位注入0.9%氯化钠注射液。造模成功后,桃叶珊瑚苷组于术后2 h给予桃叶珊瑚苷4.2 mg/kg,腹腔注射,每日1次。而假手术组及脑出血组在同样时间给予相同剂量0.9%氯化钠注射液。每组设置12 h、2 d、3 d、5 d、7 d等5个时间点,Longa评分法评估神经功能缺损,免疫...

Objective： To explore the possible mechanism of Aucubin to neuroprotection by inhibiting the ex- pression of IL-1β and NF- KB to reduce inflammatory response after cerebral hemorrhage and open up new ideas for questing cerebral hemorrhage treatment. Methods： 90 adult male Sprague Dawley rats were randomly divided into the sham operation group,the cerebral hemorrhage group and the aucubin group. Autologous blood was in- jected into the rat caudate nucleus to prepare cerebral hemorrhage, and sham operation group injected with saline at the sam...