Hmgb1 inhibits Klotho expression and malignant phenotype in melanoma cells by activating NF-kappa B

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成果类型：

期刊论文

作者：

Xie, Biao;Cao, Ke;Li, Jinjin;Chen, Jia;Tang, Jintian;...

通讯作者：

Zhou, Jianda;Xie, Huiqing

作者机构：

[Xie, Biao; Zhou, Jianda; Chen, Jia] Cent S Univ, Xiangya Hosp 3, Dept Plast Surg, Changsha 410013, Hunan, Peoples R China.

[Xie, Biao] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Colorectal Surg, Changsha 410005, Hunan, Peoples R China.

[Cao, Ke] Cent S Univ, Xiangya Hosp 3, Dept Oncol, Changsha 410013, Hunan, Peoples R China.

[Tang, Jintian] Tsinghua Univ, Inst Med Phys & Engn, Dept Engn Phys, Beijing 100084, Peoples R China.

[Chen, Xiang] Cent S Univ, Xiangya Hosp, Dept Dermatol, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Zhou, Jianda; Xie, Huiqing] C

Cent S Univ, Xiangya Hosp 3, Dept Plast Surg, Changsha 410013, Hunan, Peoples R China.

Cent S Univ, Xiangya Hosp 3, Dept Rehabil, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

Hmgb1;NF-kappa B;melanoma;Klotho;insulin signaling

期刊：

Oncotarget

ISSN：

1949-2553

年：

2016

卷：

期：

页码：

80765-80782

DOI：

10.18632/oncotarget.12623

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81572689, 81372140, 81301688, 81272192]; Ph.D. Programs Foundation of Ministry of Education of ChinaMinistry of Education, China [20130162110050, 20130162120093]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [13JJ4028]; Project of the Department of Science and Technology of Hunan Province [2013FJ6003]

机构署名：

本校为其他机构

院系归属：

第二中医临床医学院

摘要：

The molecular and cellular mechanisms behind the involvement of inflammation in melanoma have not been fully elucidated. In this study, knockdown of Hmgb1 expression increased apoptosis, reduced invasion and p-NF-kappa B expression, but increased Klotho protein level in melanoma tumor cells. The effect of Hmgb1 knockdown was overcome by LPS. Introduction of exogenous Hmgb1 significantly decreased apoptosis, increased invasion, elevated p-NF-kappa B, but lowered Klotho protein level in melanoma cells. The effect of exogenous Hmgb1 was agonized by NF-kappa B inhibitor CAPE. Hmgb1 knockdown activ...

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Hmgb1 inhibits Klotho expression and malignant phenotype in melanoma cells by activating NF-kappa B

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