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Astragaloside-IV modulates NGF-induced osteoblast differentiation via the GSK3 beta/beta-catenin signalling pathway

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成果类型:
期刊论文
作者:
Sun, Nan-Yang;Liu, Xiao-Lan;Gao, Juan;Wu, Xiao-Hui;Dou, Ben*
通讯作者:
Dou, Ben
作者机构:
[Liu, Xiao-Lan; Dou, Ben; Sun, Nan-Yang; Gao, Juan; Wu, Xiao-Hui] Hunan Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Orthoped, 233 Caie North Rd, Changsha 410005, Hunan, Peoples R China.
通讯机构:
[Dou, Ben] H
Hunan Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Orthoped, 233 Caie North Rd, Changsha 410005, Hunan, Peoples R China.
语种:
英文
关键词:
astragaloside-IV;osteogenesis;bone marrow-derived mesenchymal stem cells;neuronal growth factor;glycogen synthase kinase 3 beta
期刊:
MOLECULAR MEDICINE REPORTS
ISSN:
1791-2997
年:
2021
卷:
23
期:
1
机构署名:
本校为第一且通讯机构
院系归属:
第二中医临床医学院
摘要:
Astragaloside (AST) is derived from the Chinese herb Astragalusmembranaceus, and studies have demonstrated that it promotes differentiation of bone marrow‑derived mesenchymal stem cells (BMSCs). To the best of our knowledge, however, the functions of the component AST‑IV in osteogenesis have not previously been elucidated. The present study aimed to verify the effects of AST‑IV in osteogenesis. First, the proliferation and differentiation status of human BMSCs incubated with AST‑IV were analysed and compared with a control (no AST‑IV treat...

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