期刊论文

中文

中医药学报

1002-2392

2020

48

3

32-37

10.19664/j.cnki.1002-2392.200046

湖南省自然科学基金(2018JJ6038) 湖南省中医药科研计划项目(201703) 湖南省重点实验室开放基金计划项目(2014XNFZ03) 湖南省中医药管理局重点课题(201303) 湖南省科技厅科研项目(2013SK3103) 湖南省科技创新项目投资计划。

本校为第一机构

目的:探讨柴胡三参汤治疗缺血性心律失常多靶点、多通路的作用机制。方法:在TCMSP平台筛选柴胡三参汤活性成分,在PubChem和Swiss Target Prediction数据库进行靶标预测;在GeneCards数据库检索缺血性心律失常的靶点;构建韦恩图得到药物与疾病共同靶点;在STRING构建蛋白互作网络图（PPI）;在Cytoscape软件得到各靶点的degree值,建立簇状条形图;进行GO生物功能注释和KEGG通路富集分析。结果:本研究共挖掘到柴胡三参汤215种活性成分及1 319个作用靶点、疾病靶点120个、药物-疾病共同靶点43个,共同靶点主要富集在221个生物过程、14条信号通路上。结论:柴胡三参汤可能主要是通过调节白蛋白（ALB）、白...

Objective:To explore the multi-target and multi-pathway action mechanism of Chaihu Sanshen Decoction in treating ischemic arrhythmia.Methods:The active components of Chaihu Sanshen Decoction were screened on the TCMSP platform,and the targets were predicted in the PubChem and Swiss Target Prediction databases.The target of the disease was retrieved in the GeneCards database.The Venn diagram was used to obtain the common targets of drugs and diseases.Protein-protein interaction(PPI)was constructed in STRING,the degree of each target was obtained in Cytoscape,and a cluster bar chart was establis...