期刊论文

中文

湖南中医药大学学报

1674-070X

2009

29

1

26-28

10.3969/j.issn.1674-070X.2009.01.009

湖南省科技计划重点资助项目（2007FJ2005）；

本校为第一机构

目的 探讨寿胎丸对反复自然流产小鼠母胎界面SOCS1和SOCS3蛋白表达的影响.方法 采用CBA/JxBALB/C建立正常妊娠小鼠模型,CBA/JxDBA/2建立反复自然流产小鼠模型,并将流产模型小鼠随机分为4组,分别为反复自然流产模型对照组及寿胎丸低、中、高剂量组,寿胎丸低、中、高剂量组从妊娠第0天开始灌胃给药,14 d后处死小鼠,取其蜕膜和胎盘组织,Westem blot分别检测SOCS1和SOCS3蛋白的表达.结果 寿胎丸低、中、高剂量组均可降低反复自然流产小鼠母胎界面SOCS1蛋白的表达,差异具有统计学意义(P0.05);寿胎丸中、高剂量组可升高反复自然流产小鼠母胎界面SOCS3蛋白的表达,差异具有统计学意义(P0.05).结论 寿胎丸...

Objective To study the effects of Shoutai pills on the protein expression of SOCS1 and SOCS3 in maternal-fetal interface of mice with recurrent spontaneous abortion（RSA）. Methods The Normal pregnancy and RSA model were respectively induced with CBA/J×BALB/C and CBA/J×DBA/2. The mice with RSA were randomly divided into model group and low, middle and high dose groups of Shoutai pills. The mice were killed in 14 days after administration and their decidual and placental tissues were used to detect the protein expressions of SOCS1 and SOCS3 wi...