期刊论文

英文

Phytomedicine

0944-7113

2023

114

154775

10.1016/j.phymed.2023.154775

National Nature Science Foundation of China [U21A20411, 82074400]; National key R & D program of China [2018YFC1704400]; Talents Project of Hunan Province Science and Technology [2022RC1227]; Key Research and Development Project of Hunan Province Science and Technology [2022GK4015, 2020SK2029, 2020SK2101]; Project of Changsha Technology Innovation Center [kh2004018]; Training Program for Excellent Young Innovators of Changsha [kq1802017]; Research Project of Traditional Chinese Medicine Bureau of Hunan Province [A2023020]; Program of Survey of Chinese Medicines of China; Research on the Comprehensive Development and Utilization of Characteristic Traditional Chinese Medicine Resources; Key project of Hunan Academy of Traditional Chinese Medicine; Graduate Student Innovation Project of Hunan University of Traditional Chinese Medicine; [[2017]66]; [2060302]; [202103]; [2022CX188]

本校为第一机构

BACKGROUND: Nowadays, diabetic kidney disease (DKD) has become one of the most threatening to the end-stage renal diseases, and the early prevention of DKD is inevitable for Diabetes Mellitus (DM) patients. AIMS: Pyroptosis, a programmed cell death that mediates renal inflammation induced early renal injury. The trimethylamine n-oxide (TMAO) was also an independent risk factor for renal injury. Here, the associations between TMAO-induced pyroptosis and pathogenesis of DKD were studied, and the potential mechanism of Zuogui-Jiangtang-Yishen (ZGJTYS) decoction to prevent DKD was further investig...