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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Xiangyun;Sun, Taoli;Liu, Jiaqin;Wei, Shanshan;Yang, Yuanying;...

通讯作者：

Zhang, Bikui;Li, WQ

作者机构：

[Liu, Jiaqin; Yang, Yuanying; Zhang, Bikui; Li, Wenqun; Li, Xiangyun; Wei, Shanshan; Liu, Jian] Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China.

[Liu, Jiaqin; Yang, Yuanying; Li, Xiangyun; Wei, Shanshan; Liu, Jian; Li, Wenqun; Zhang, Bikui] Cent South Univ, Inst Clin Pharm, Changsha 410011, Hunan, Peoples R China.

[Li, Xiangyun; Zhang, Bikui] Cent South Univ, Xiangya Hosp, Dept Pharm, Changsha 410008, Hunan, Peoples R China.

[Sun, Taoli] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Zhang, BK; Li, WQ ] C

Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

Cardiotoxicity;Doxorubicin;Fos;Hif3a;Phloretin;RNA sequencing

期刊：

Phytomedicine

ISSN：

0944-7113

年：

2023

卷：

120

页码：

155046

DOI：

10.1016/j.phymed.2023.155046

基金类别：

National Natural Scientific Foundation of China [82173911, 81973406, 82373970]; Hunan Provincial Natural Scientific Foundation [2023JJ30761, 2023JJ30802, 2022JJ80109]; Scientific Research Project of Hunan Provincial Health and Family Planning Commission [202113050843, CPA-Z05-ZC-2021-002]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

BACKGROUND: Doxorubicin (Dox), a chemotherapeutic agent known for its efficacy, has been associated with the development of severe cardiotoxicity, commonly referred to as doxorubicin-induced cardiotoxicity (DIC). The role and mechanism of action of phloretin (Phl) in cardiovascular diseases are well-established; however, its specific function and underlying mechanism in the context of DIC have yet to be fully elucidated. OBJECTIVE: This research aimed to uncover the protective effect of Phl against DIC in vivo and in vitro, while also providing a comprehensive understanding of the underlying m...

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