Mir-34a enhances the susceptibility of gastric cancer to platycodin d by targeting survivin

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成果类型：

期刊论文

作者：

Peng, Yao;Fan, Jing-Ying;Xiong, Jian;Lou, Yu;Zhu, Ying

通讯作者：

Zhu, Y

作者机构：

[Peng, Yao] Hunan Univ Tradit Chinese Med, Affiliated Hosp 2, Intens Care Unit, Changsha, Peoples R China.

[Fan, Jing-Ying] Hunan Univ Tradit Chinese Med, Coll Integrated Chinese & Western Med, Changsha, Peoples R China.

[Xiong, Jian; Lou, Yu] Hunan Univ Tradit Chinese Med, Grad Sch, Changsha, Peoples R China.

[Zhu, Ying; Zhu, Y] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Gastroenterol, 95 Shaoshan Middle Rd, Changsha 410000, Peoples R China.

通讯机构：

[Zhu, Y ] H

Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Gastroenterol, 95 Shaoshan Middle Rd, Changsha 410000, Peoples R China.

语种：

英文

关键词：

antineoplastic agent;caspase 3;caspase 7;microRNA 34a;platycodin D;protein Bax;protein bcl 2;saponin derivative;survivin;triterpenoid;unclassified drug;BIRC5 protein, human;microRNA;MIRN34 microRNA, human;platycodin D;saponin;survivin;triterpene;AGS cell line;animal experiment;animal model;animal tissue;antineoplastic activity;apoptosis;Article;cancer chemotherapy;cancer susceptibility;controlled study;down regulation;gene expression;HGC-27 cell line;human;human cell;in vitro study;in vivo study;MKN28 cell line;mouse;NCI-N87 cell line;nonhuman;priority journal;protein expression;protein targeting;SGC-7901 cell line;stomach cancer;tumor xenograft;animal;cell proliferation;drug effect;drug screening;gene expression regulation;genetic predisposition;genetics;nude mouse;stomach tumor;tumor cell line;Animals;Apoptosis;Cell Line, Tumor;Cell Proliferation;Gene Expression Regulation, Neoplastic;Genetic Predisposition to Disease;Humans;Mice;Mice, Nude;MicroRNAs;Saponins;Stomach Neoplasms;Survivin;Triterpenes;Xenograft Model Antitumor Assays

期刊：

PATHOBIOLOGY

ISSN：

1015-2008

年：

2019

卷：

期：

5-6

页码：

296-305

DOI：

10.1159/000502913

基金类别：

This work was supported by the study of survivin-RNA gene silence enhancing the sensitivity of gastric cancer cells to traditional Chinese medicine Sanwubai powder (No. 81503561).

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

第二中医临床医学院

中西医结合学院

研究生院

摘要：

Introduction: Platycodin D (PD), a triterpenoid saponin isolated from Platycodon grandiflorum, has a well-known anti-Tumor effect in multiple human cancers, including gastric cancer (GC). miR-34a plays an important role in the progression of GC. However, the relationship between miR-34a and the susceptibility of GC cells to PD is still unclear. The aim of our research was to investigate the functions of miR-34a in mediating the susceptibility of GC to PD. Methods: qPCR was performed to detect the expression level of miR-34a and survivin in GC c...

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Mir-34a enhances the susceptibility of gastric cancer to platycodin d by targeting survivin

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