Total saponins from Lilium lancifolium: A promising alternative to inhibit the growth of gastric carcinoma cells

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成果类型：

期刊论文

作者：

Zhang, Yin-Yu;Luo, Lin-Ming;Wang, Yu-Xiang;Zhu, Neng;Zhao, Tan-Jun;...

通讯作者：

Qin, L

作者机构：

[Luo, Lin-Ming; Zhang, Yin-Yu; Qin, Li; Zhao, Tan-Jun; Wang, Yu-Xiang] Hunan Univ Chinese Med, Sch Pharm, Div Stem Cell Regulat & Applicat, Changsha, Peoples R China.

[Zhu, Neng] Hunan Univ Chinese Med, Hosp 1, Changsha, Peoples R China.

通讯机构：

[Qin, L ] H

Hunan Univ Chinese Med, Sch Pharm, Div Stem Cell Regulat & Applicat, Changsha, Peoples R China.

语种：

英文

关键词：

antineoplastic agent;cisplatin;cycline;gelatinase A;Lilium lancifolium extract;plant extract;protein Bax;protein bcl 2;protein p21;saponin;tissue inhibitor of metalloproteinase 1;unclassified drug;antineoplastic activity;antiproliferative activity;apoptosis;Article;cancer inhibition;carcinoma cell;cell invasion;cell migration;cell proliferation;controlled study;down regulation;drug activity;drug cytotoxicity;drug effect;drug mechanism;edible plant;HGC-27 cell line;human;human cell;Lilium lancifolium;lily;medicinal plant;protein expression;SGC-7901 cell line;stomach carcinoma;upregulation

期刊：

JOURNAL OF CANCER

ISSN：

1837-9664

年：

2020

卷：

期：

页码：

4261-4273

DOI：

10.7150/jca.42285

基金类别：

This work is supported by grants from the National Natural Sciences Foundation of China (No. 819736668, No. 81774130, No. 81270359, and No. 81000946), the National Science Fund of Hunan Province for Distinguished Young Scholars (No. 2018JJ1018), Open Funds of State Key Laboratory of Oncology in South China (HN2019-07), and the First-Class Discipline of Pharmaceutical Science of Hunan.

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

药学院

摘要：

Bulbus Lilii, as a medicinal and edible plant, has anti-inflammatory, anti-oxidative and immunopotentiating pharmacological activities, which seems to be therapeutic on cancer prevention. The purpose of this study was to investigate the effects of total saponins from Lilium lancifolium (TSLL) on proliferation, apoptosis and migration of human gastric carcinoma cells lines SGC-7901 and HGC-27 and its underlying mechanism. The results showed that TSLL inhibited the proliferation of gastric carcinoma cells by suppressing the level of proliferating...

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Total saponins from Lilium lancifolium: A promising alternative to inhibit the growth of gastric carcinoma cells

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