期刊论文

Effect of qi-tonifying and detoxicating prescription on CD4^＋CD25^＋regulatory T cells in patients with advanced nasopharyngeal carcinoma

中文

湖南中医杂志

1003-7705

2013

29

5

9-11

10.16808/j.cnki.issn1003-7705.2013.05.005

湖南省中医药科研计划项目（编号:2010007）；

本校为第一机构

目的：探讨益气解毒方对中晚期鼻咽癌患者CD4^＋CD25^＋调节性T细胞的作用。方法：将30例该病患者随机分为对照组与观察组各15例,对照组采用常规治疗,观察组在常规治疗基础上加中药益气解毒方治疗,两组均于开始治疗前1周及治疗3个月后第1周用流式细胞仪检测患者外周血CD4^＋CD25^＋调节性T细胞比例,ELISA法检测血清白介素10（IL-l0）和转化因子-β（TGF-β）水平。结果：观察组患者外周血中CD4^＋CD25^＋调节性T细胞占CD4^＋T细胞的百分比低于对照组（P〈0.05）;血清IL-10和TGF-β水平亦低于对照组（P〈0.05）。结论：益气解毒方能降低中晚期鼻咽癌CD4^＋CD25^＋调节性T细胞的比例,其机制可能是...

Objective：To investigate the effect of qi-tonifying and detoxicating prescription on CD4^＋CD25^＋ regulatory T cells（Tregs） in patients with advanced nasopharyngeal carcinoma.Methods：Thirty patients with advanced nasopharyngeal carcinoma were randomly divided into control group（n = 15） and observation group（n = 15）.The control group received conventional treatment,while the observation group received conventional treatment plus qi tonifying and detoxicating prescription of traditional Chinese medicine.In the first week of treatment and...