Study of Linearization of Hill Dose-Effect Curve with Metabolic Velocity Instead of Drug Concentration

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成果类型：

期刊论文

作者：

刘润南;唐昱;刘平安;刘文龙;樊启猛;...

通讯作者：

HE, F.-Y.

作者机构：

[唐昱; 李海英; 陈思阳] Department of Pharmaceutic, Hunan University of Chinese Medicine, Hunan, Changsha, 410208, China

[刘平安] Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Hunan, Changsha, 410208, China

Department of Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medicine, Hunan University of Chinese Medicine, Hunan, Changsha, 410208, China

[邓凯文] The First Affiliated Hospital of Hunan University of Chinese Medicine, Hunan, Changsha, 410208, China

[刘润南; 贺福元; 刘文龙; 樊启猛; 贺鹏] Department of Pharmaceutic, Hunan University of Chinese Medicine, Hunan, Changsha, 410208, China, Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Hunan, Changsha, 410208, China, Department of Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medicine, Hunan University of Chinese Medicine, Hunan, Changsha, 410208, China

通讯机构：

[HE, F.-Y.] D

Department of Pharmaceutic, Hunan, China

语种：

中文

关键词：

Hill量效方程;速效方程;药(谱)效动力学;药(谱)效学;药(谱)动学;中药复方有效性;乙酰胆碱;肾上腺素;定量药理学

关键词(英文)：

Hill dose-effect equation;Velocity-effect equation;Pharmacodynamics with chromatographic fingerprint (PDCF);Pharmacy metrology with chromatographic fingerprint (PMCF);Pharmacokinetics with chromatographic fingerprint (PKCF);Availability of CMM formulas;Acetylcholine;Adrenalin;Quantitative pharmacology

期刊：

数字中医药(英文)

ISSN：

2096-479X

年：

2018

卷：

期：

页码：

198-210

DOI：

10.1016/S2589-3777(19)30027-8

基金类别：

We thank for the funding support from the National Natural Science Foundation of China (No. 81073142 and No. 30901971).

机构署名：

本校为第一机构

院系归属：

药学院

摘要：

Objective To explore the velocity-effect relationship in order to the establish linearization of effect on an equation with regard to the consistency of the Hill dose-effect expression with the metabolic kinetics of receptors. Methods The linear velocity-effect expression was obtained by solving multivariant differential equation groups, which were established to compare the coincidences and basic relations between the Hill dose-effect and metabolic kinetic Michaelis-Menten equation for receptors. The validation test was conducted with acetylch...

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Study of Linearization of Hill Dose-Effect Curve with Metabolic Velocity Instead of Drug Concentration

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