Fructus Lycii and Salvia miltiorrhiza Bunge extract alleviate retinitis pigmentosa through Nrf2/HO-1 signaling pathway

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成果类型：

期刊论文

作者：

Ou, Chen*;Jiang, Pengfei*;Tian, Ye*;Yao, Zhen*;Yang, Yijing*;...

通讯作者：

Ou, Chen;Jiang, Pengfei;Tian, Ye;Yao, Zhen;Yang, Yijing;Peng, Jun;Zeng, Meiyan;Song, Houpan;Peng, Qinghua

作者机构：

[Yao, Zhen; Jiang, Pengfei; Ou, Chen; Peng, Qinghua; Yang, Yijing; Tian, Ye; Song, Houpan] Hunan Univ Chinese Med, Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha 410208, Hunan, Peoples R China.

[Peng, Jun; Peng, Qinghua] Hunan Univ Chinese Med, Dept Ophthalmol, Affiliated Hosp 1, Changsha 410007, Hunan, Peoples R China.

[Jiang, Pengfei; Ou, Chen; Peng, Qinghua; Zeng, Meiyan; Song, Houpan] Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost Res Chinese Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Jiang, Pengfei; Peng, Qinghua; Ou, Chen; Zeng, Meiyan; Yang, Yijing; Yao, Zhen; Song, Houpan; Tian, Ye] H

[Peng, Jun] D

Hunan Provincial Key Laboratory of Diagnostic Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China. Electronic address:

Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China. Electronic address:

Department of Ophthalmology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, 410007, China. Electronic address:

语种：

英文

关键词：

Fructus Lycii;HO-1;Nrf2;Oxidative stress;Retinitis pigmentosa;Salvia miltiorrhiza Bunge

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2021

卷：

273

页码：

113993-

DOI：

10.1016/j.jep.2021.113993

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81804150, 82004427]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M662790]; Hunan Postgraduate Scientific Research Innovation Project [CX20190586]; Domestic FirstClass Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine; Hunan Engineering Technology Research Center for the Prevention and Treatment of Otorhinolaryngologic Diseases and Protection of Visual Function with Chinese Medicine; Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine

机构署名：

本校为第一机构

院系归属：

第一中医临床学院

摘要：

ETHNOPHARMACOLOGICAL RELEVANCE: Fructus Lycii and Salvia miltiorrhiza Bunge (FS) are popular Chinese herbs for the treatment of retinitis pigmentosa (RP). AIM OF THE STUDY: This study was to evaluate protective effects of FS extract on RP and to explore whether FS extract exerts its protective effects via oxidative stress by regulating Nrf2/HO-1 signaling pathway. MATERIAL AND METHODS: FS extract were identified by UPLC chromatographic analysis. Rd10 mice as the model of RP, followed by a 4-week FS extract treatment by intragastric administration. After the animal sacrifice, histopathological ...

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Fructus Lycii and Salvia miltiorrhiza Bunge extract alleviate retinitis pigmentosa through Nrf2/HO-1 signaling pathway

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