Fructus Lycii and Salvia miltiorrhiza Bunge extract attenuate oxidative stress-induced photoreceptor ferroptosis in retinitis pigmentosa

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成果类型：

期刊论文

作者：

Yang, Yijing;Wang, Ying;Deng, Ying;Lu, Jing;Xiao, Li;...

通讯作者：

Peng, QH

作者机构：

[Peng, QH; Nie, Fujiao; Peng, Jun; Tan, Hanyu; Peng, Qinghua; Yang, Yijing; Wang, Ying; Zhou, Yasha; Qin, Yuhui; Deng, Ying; Li, Jie; Lu, Jing; Xiao, Li; Chen, Xiangdong] Hunan Univ Chinese Med, 300 Xueshi Rd, Changsha 410208, Peoples R China.

[Peng, Jun; Tan, Hanyu; Peng, Qinghua; Yang, Yijing; Wang, Ying; Qin, Yuhui; Deng, Ying; Li, Jie; Lu, Jing] Inst Ophthalmol & Otolaryngoloy Chinese Med, Changsha 410208, Peoples R China.

[Nie, Fujiao; Peng, Jun; Peng, Qinghua; Yang, Yijing; Qin, Yuhui; Chen, Xiangdong] Tradit Chinese Med, Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha 410208, Peoples R China.

[Qin, Yuhui; Chen, Xiangdong] Hunan Univ Chinese Med, Dept Ophthalmol, Affiliated Hosp 1, Changsha 410007, Peoples R China.

[Tan, Hanyu] Hunan Univ Tradit Chinese Med, Yueyang Hosp, Yueyang 414000, Peoples R China.

通讯机构：

[Peng, QH ] H

Hunan Univ Chinese Med, 300 Xueshi Rd, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Ferroptosis;Fructus Lycii;Oxidative stress;Retinitis Pigmentosa;Salvia miltiorrhiza Bunge

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2023

卷：

167

页码：

115547

DOI：

10.1016/j.biopha.2023.115547

基金类别：

National Natural Science Foundation of China [82274341, 82274588]; Scientific Research Project of Traditional Chinese Medicine of Hunan Province [B2023041]; Qihuang Scholars Support Project of Peng Qinghua; Scientific research project of Hunan Provincial Department of Education [21B0391]; Natural Science Foundation of Hunan Province [2023JJ40475, 2023JJ50307]; Academician Liu Liang Workstation Guidance Project [22YS003]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

AIM OF THE STUDY: To assess the impact of Fructus Lycii and Salvia miltiorrhiza Bunge extract (FSE) on retinitis pigmentosa (RP) and to explore the mechanisms by which FSE can prevent oxidative stress-induced photoreceptor ferroptosis in RP. METHODS: Hydrogen peroxide(H(2)O(2)) was used to induce oxidative stress in 661W cells, which were then examined using flow cytometry and enzyme linked immunosorbent assay (ELISA). Changes in mitochondria were observed by using an electron microscope to characterize the ferroptosis of the cells. The protective effect of FSE on the retina function and struc...

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Fructus Lycii and Salvia miltiorrhiza Bunge extract attenuate oxidative stress-induced photoreceptor ferroptosis in retinitis pigmentosa

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