Berberine Derivatives with Different Pharmacological Activities via Structural Modifications

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成果类型：

期刊论文

作者：

Xiao, Daipeng;Liu, Zhenbao;Zhang, Shanshan;Zhou, Mi;He, Fen;...

通讯作者：

Liu, Yanfei;Peng, Dongming

作者机构：

[Liu, Yanfei; Xie, Xiong; Zhang, Shanshan; He, Fen; Xiao, Daipeng] Cent S Univ, Sch Chem & Chem Engn, Dept Pharmaceut Engn, POB 410083, Changsha 410083, Hunan, Peoples R China.

[Zhou, Mi; Peng, Dongming; Peng, Junying; Zou, Ming] Hunan Univ Chinese Med, Sch Pharm, Dept Med Chem, POB 410208, Changsha 410208, Hunan, Peoples R China.

[Liu, Zhenbao] Cent S Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmaceut, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Liu, Yanfei] C

[Peng, Dongming] H

Cent S Univ, Sch Chem & Chem Engn, Dept Pharmaceut Engn, POB 410083, Changsha 410083, Hunan, Peoples R China.

Hunan Univ Chinese Med, Sch Pharm, Dept Med Chem, POB 410208, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Berberine;bioavailability;chemical transformation;mechanisms;pharmacological activities;structural modification.

期刊：

Mini-Reviews in Medicinal Chemistry

ISSN：

1389-5575

年：

2018

卷：

期：

页码：

1424-1441

DOI：

10.2174/1389557517666170321103139

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81301258]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2016JJ2161, 2017JJ2346]; Specialized Research Fund for the Doctoral Program of Higher Education of ChinaSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20130162120078]; Fundamental Research Funds for the Central Universities of Central South University; Shenghua Yuying Project of Central South University

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

Berberine, a quaternary ammonium protoberberine alkaloid with an isoquinoline scaffold isolated from medicinal herbs, exhibits a wide spectrum of pharmacological activities. Berberine has been used in traditional Chinese medicine and Ayurvedic medicine. However, it has poor bioavailability, which seriously limits its application and development. The chemical transformation of natural products is an effective method to improve pharmacological activities. Researches have been carried out on the modification of berberine to obtain better pharmacological properties. In this paper, the structural m...

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Berberine Derivatives with Different Pharmacological Activities via Structural Modifications

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