MicroRNA-582-3p negatively regulates cell proliferation and cell cycle progression in acute myeloid leukemia by targeting cyclin B2

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Haixia;Tian, Xuefei*;Wang, Paoqiu;Huang, Mao;Xu, Ronghua;...

通讯作者：

Tian, Xuefei;Nie, Tian

作者机构：

[Li, Haixia; Wang, Paoqiu] Hunan Childrens Hosp, Dept Integrated Chinese & Western Med, Changsha 410007, Peoples R China.

[Li, Haixia] Hunan Univ Chinese Med, Changsha 410208, Peoples R China.

[Tian, Xuefei] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Changsha 410208, Peoples R China.

[Huang, Mao] Hebei Prov Hosp Tradit Chinese Med, Dept Pediat Rehabil, Shijiazhuang 050000, Hebei, Peoples R China.

[Xu, Ronghua; Nie, Tian] Hunan Univ Chinese Med, Hosp 1, Dept Hematol, 95 Shaoshan Middle Rd, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Tian, Xuefei; Nie, Tian] H

Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Changsha 410208, Peoples R China.

Hunan Univ Chinese Med, Hosp 1, Dept Hematol, 95 Shaoshan Middle Rd, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

Acute myeloid leukemia;CCNB2;Cell cycle;miR-582-3p

期刊：

Cellular & Molecular Biology Letters

ISSN：

1689-1392

年：

2019

卷：

期：

页码：

1-12

DOI：

10.1186/s11658-019-0184-7

基金类别：

Major Project of the Hunan Administration of Traditional Chinese Medicine [201817]; 64th General Project of China Postdoctoral Science Foundation [2018 M642982]

机构署名：

本校为通讯机构

院系归属：

第一中医临床学院

中西医结合学院

摘要：

MicroRNAs (miRNAs) function as post-transcriptional gene expression regulators. Some miRNAs, including the recently discovered miR-582–3p, have been implicated in leukemogenesis. This study aimed to reveal the biological function of miR-582–3p in acute myeloid leukemia (AML), which is one of the most frequently diagnosed hematological malignancies. The expression of miR-582–3p was determined using quantitative real-time PCR in blood samples from leukemia patients and in cell lines. Cell proliferation and cell cycle distribution were analyzed...

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MicroRNA-582-3p negatively regulates cell proliferation and cell cycle progression in acute myeloid leukemia by targeting cyclin B2

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