Genistein Protects H9c2 Cardiomyocytes against Chemical Hypoxia-Induced Injury via Inhibition of Apoptosis.

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成果类型：

期刊论文

作者：

Shi, Ya-Ning;Zhang, Xiu-Qin;Hu, Zhe-Yu;Zhang, Chan-Juan;Liao, Duan-Fang;...

通讯作者：

Qin, Li;Huang, Hong-Lin

作者机构：

[Shi, Ya-Ning; Zhang, Chan-Juan; Liao, Duan-Fang; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Shi, Ya-Ning; Zhang, Chan-Juan; Liao, Duan-Fang; Qin, Li] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

[Huang, Hong-Lin; Zhang, Xiu-Qin] Univ South China, Dept Pharmacol, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

[Hu, Zhe-Yu] Cent S Univ, Hunan Canc Hosp, Changsha, Hunan, Peoples R China.

[Hu, Zhe-Yu] Cent S Univ, Affiliated Canc Hosp, Xiangya Med Sch, Changsha, Hunan, Peoples R China.

通讯机构：

[Qin, Li] H

[Huang, Hong-Lin] U

Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

Univ South China, Dept Pharmacol, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Cardiomyocytes;Genistein;Hypoxia

期刊：

Research Reviews in Pharmacology

ISSN：

0031-7012

年：

2019

卷：

103

期：

5-6

页码：

282-290

DOI：

10.1159/000497061

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270359, 81774130, 81670268]; Key Projects of Hunan Traditional Chinese Medicine Administration [201614]; Science Foundation for Distinguished Young Scholars of Hunan ProvinceNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [2018JJ1018]; Natural Science Foundation of GuangdongNational Natural Science Foundation of Guangdong Province [2016A030313026]; Hunan Provincial Key Discipline of Pharmaceutical Science

机构署名：

本校为第一机构

院系归属：

药学院

摘要：

BACKGROUND/AIMS: Hypoxia can induce cell injury in cardiomyocytes and further lead to cardiovascular diseases. Genistein (Gen), the predominant isoflavone found in soy products, has shown protective effects on cardiovascular system. The aim of the present study was to investigate the cardioprotective effect of Gen against chemical hypoxia-induced injury. METHODS: Cobalt chloride (CoCl2) was administrated to trigger chemical hypoxia in H9c2 cardiomyocytes. Cell proliferation was detected by using MTT assay. The expression level of hypoxia-related proteins (hypoxia-inducible factor [HIF]-1alpha ...

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Genistein Protects H9c2 Cardiomyocytes against Chemical Hypoxia-Induced Injury via Inhibition of Apoptosis.

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