The key aspect of syndrome study is methodology breakthroughs. TCM syndrome is a non- linear system of complex giant system. From the perspective of complexity science to seek syndrome research methodology is the impor- tant way. The introduction of artificial neural network to TCM syndrome research consistents with the TCM syndrome con- notation system requirements, and is feasible. The topics focus on TCM syndrome characteristics of the complexity of the system to explore the standardization of TCM syndrome research methodology, designed for t...