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Causal relationship between immune cells and heart failure: A Mendelian randomization study

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成果类型:
期刊论文
作者:
Lu, Shenghua;Yu, Yunfeng;Zhu, Zheqin;Wang, Min;Liu, Rongzhen;...
通讯作者:
Liu, JH
作者机构:
[Yu, Yunfeng; Zhu, Zheqin; Liu, Jianhe; Lu, Shenghua; Liu, Rongzhen; Wang, Min] Hunan Univ Chinese Med, Clin Coll Chinese Med 1, Changsha 410007, Hunan, Peoples R China.
[Zhu, Zheqin; Liu, Jianhe; Lu, Shenghua; Wang, Min] Hunan Univ Chinese Med, Hosp 1, Branch Natl Clin Res Ctr Chinese Med Cardiol, Changsha, Hunan, Peoples R China.
通讯机构:
[Liu, JH ] H
Hunan Univ Chinese Med, Clin Coll Chinese Med 1, Changsha 410007, Hunan, Peoples R China.
语种:
英文
关键词:
genetic susceptibility;heart failure;immune cells;Mendelian randomization;phenotypes
期刊:
MEDICINE
ISSN:
1357-3039
年:
2025
卷:
104
期:
2
页码:
e41247
基金类别:
Hunan University of Chinese Medicine 2023 Double First-class Discipline Construction--Research on Traditional Chinese Medicine to Prevent and Control Heart and Brain Diseases#&#&#6001001006 Hunan Province Financial Traditional Chinese Medicine Project#&#&#D2023005
机构署名:
本校为第一且通讯机构
院系归属:
第一中医临床学院
摘要:
This study aimed to evaluate the causal effects of different immune cells on heart failure (HF) using Mendelian randomization (MR). Datasets for immune cell phenotypes and HF were obtained from European Bioinformatics Institute and FinnGen. Then, single nucleotide polymorphisms were screened according to the basic assumptions of MR. Subsequently, inverse variance weighted was used as primary tool for MR analysis, and Cochran Q and leave-one-out analyses were used to assess heterogeneity and robustness, respectively. MR analysis showed that clus...

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