Testosterone attenuates senile cavernous fibrosis by regulating TGF beta R1 and galectin-1 signaling pathways through miR-22-3p

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu, Zongren;Zhang, Yuanting;Chen, Jisong;Luo, Min;Wang, Neng;...

通讯作者：

Qinghu He

作者机构：

[Luo, Min; Chen, Jisong; Hu, Zongren; He, Qinghu] Hunan Univ Med, Dept Rehabil & Healthcare, 492 Jinxi South Rd, Huaihua City, Hunan, Peoples R China.

[Wang, Neng; Hu, Zongren; He, Qinghu] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

[Zhang, Yuanting] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha 410007, Hunan, Peoples R China.

[Luo, Min] Cent South Univ, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.

[Xiao, Yinfu] Hunan Univ Chinese Med, Sch Tradit Chinese Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Qinghu He] D

Department of Rehabilitation and Healthcare, Hunan University of Medicine, Huaihua City, China<&wdkj&>School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China

语种：

英文

关键词：

Erectile dysfunction;Fibrosis;Galectin-1;TGFβR1;Testosterone;miR-22-3p

期刊：

Molecular and Cellular Biochemistry

ISSN：

0300-8177

年：

2023

卷：

478

期：

页码：

1791-1802

DOI：

10.1007/s11010-022-04641-8

基金类别：

This study was funded by National Natural Science Foundation of China (No.81973863), Traditional Chinese Medicine Scientific Research Program of Hunan Province (No.2022118), Scientific research project of Hunan Provincial Department of Education (No.22B1032) and Scientific Research Program of Hunan Provincial Health Commission (No.D202303107632).

机构署名：

本校为通讯机构

院系归属：

第一中医临床学院

中西医结合学院

摘要：

Erectile dysfunction (ED) is a major health problem affecting a large proportion of the general population. Testosterone also plays a key role in sexual dysfunction. In this study, we found that testosterone can inhibit cavernous fibrosis by affecting the expression of miR-22-3p, providing a new basis for research and treatment of ED. Old and young rats were used to study the effects of testosterone on cavernous fibrosis. Hematoxylin and eosin (HE) and Masson's staining were used to observe the cavernous tissue. A luciferase assay was used to analyze the relationship between the miR-22-3p, TGF...

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Testosterone attenuates senile cavernous fibrosis by regulating TGF beta R1 and galectin-1 signaling pathways through miR-22-3p

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