期刊论文

The Pharmacological Effects of Effective Fractions Extracted from Buyang Huanwu Decoction on the Infiltration of Polymorphonuclear Leukocytes in the Local Cerebral Focus Induced by Ischemia Reperfusion among Rats

中文

湖南中医药大学学报

1674-070X

2003

23

6

1-3

10.3969/j.issn.1674-070X.2003.06.001

国家自然科学基金项目 （ 3 0 17113 2 ）； 教育部高等学校学术与技术带头人资助计划项目； 湖南省优秀博士论文作者科研项目；

本校为第一机构

目的研究补阳还五汤(BYHWD)中生物碱、多糖、苷、苷元4类有效成分部位对大鼠大脑中动脉闭塞(MACO)后局灶性脑缺血再灌注诱导的多形核细胞(PMNL)浸润的影响.方法用颈内动脉线栓法建立大鼠MACO模型,以检测脑组织髓过氧化物酶(MPO)活性判定脑组织中多形核细胞的浸润.结果脑缺血2h再灌注46h后,脑组织MPO活性升高(P＜0.05),多糖组和生物碱组脑组织MPO活性明显低于模型组(P＜0.05).结论脑缺血再灌注后,白细胞浸润到损伤区,参与了中枢神经系统缺血后的炎症反应.补阳还五汤4类有效成分部位中多糖、生物碱能降低脑组织MPO活性,减轻大脑中动脉闭塞后再灌注脑组织中多形核细胞的浸润,这可能是补阳还五汤抗脑...

Objective To investigate the pharmacological effects of 4 kinds of effective fractions extracted from Buyang Huanwu Decoction(BHD) on the infiltration of polymorphonuclear leukocytes(PMNL)in the local cerebral focus induced by ischemia-reperfusion among rats.Methods The model of cerebral ischemia-reperfusion was prepared among rats with the method of nylon monofilament via the internal carotid artery to induce occlusion in the middle cerebral artery.Then,the 4 kinds of effective fraction were used to treat the modeling animals respectively and the activity determination of myeloperoxidase(MPO)...