Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance

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成果类型：

期刊论文

作者：

Bu, Yiwen;Cai, Guoshuai;Shen, Yi;Huang, Chenfei;Zeng, Xi;...

通讯作者：

Cao, Deliang;Liao, Duan-Fang

作者机构：

[Huang, Chenfei; Shen, Yi; Cao, Yu; Bu, Yiwen; Cao, Deliang] Southern Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N Rutledge St, Springfield, IL 62794 USA.

[Cai, Guoshuai] Geisel Sch Med Dartmouth, Dept Genet, Hanover, NH 03755 USA.

[Zeng, Xi] Univ South China, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.

[Wang, Yuhong; Cao, Deliang; Huang, Dan; Liao, Duan-Fang; Cai, Chuan] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

[Liao, Duan-Fang] Hunan Univ Tradit Chinese Med, Div Stem Cell Regulat & Applicat, 1 Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Cao, Deliang] S

[Liao, Duan-Fang] H

Southern Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N Rutledge St, Springfield, IL 62794 USA.

Hunan Univ Tradit Chinese Med, Div Stem Cell Regulat & Applicat, 1 Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

NF-kappa B RelA/p65;ABCC6;RITA;Chemoresistance

期刊：

Cancer Letters

ISSN：

0304-3835

年：

2016

卷：

383

期：

页码：

261-271

DOI：

10.1016/j.canlet.2016.10.006

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272918, 81472465]

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

Inactivation of p53 occurs frequently in various cancers. RITA is a promising anticancer small molecule that dissociates p53-MDM2 interaction, reactivates p53 and induces exclusive apoptosis in cancer cells, but acquired RITA resistance remains a major drawback. This study found that the site-differential phosphorylation of nuclear factor-kappa B (NF-kappa B) RelA/p65 creates a barcode for RITA chemosensitivity in cancer cells. In naive MCF7 and HCT116 cells where RITA triggered vast apoptosis, phosphorylation of RelA/p65 increased at Ser536, but decreased at Ser276 and Ser468; oppositely, in ...

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Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance

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