TMT-based quantitative proteomics analysis of the effects of Jiawei Danshen decoction myocardial ischemia-reperfusion injury

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成果类型：

期刊论文

作者：

Zhu, Xiang-Mei;Tan, Yang;Shi, Yu-He;Li, Qing;Zhu, Jue;...

通讯作者：

Qiao-Zhen Tong

作者机构：

[Tan, Yang; Li, Qing; Liu, Xiang-Dan; Zhu, Xiang-Mei; Shi, Yu-He; Zhu, Jue; Tong, Qiao-Zhen] Hunan Univ Chinese Med, Pharm Coll, Xueshi Rd,300, Changsha 410208, Hunan, Peoples R China.

[Zhu, Xiang-Mei] Second Hosp Hunan Univ Chinese Med, Caie North Rd,233, Changsha 410005, Hunan, Peoples R China.

[Liu, Xiang-Dan; Tong, Qiao-Zhen] Key Lab Germplasm Resources & Standardized Plantin, Xueshi Rd,300, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Qiao-Zhen Tong] P

Pharmacy of College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, People’s Republic of China<&wdkj&>Key Laboratory of Germplasm Resources and Standardized Planting of Bulk Authentic Medicinal Materials from Hunan, Changsha, Hunan 410208, People’s Republic of China

语种：

英文

关键词：

Myocardial ischemia-reperfusion injury (MIRI);Tandem mass tag (TMT);Jiawei Danshen decoction (JWDSD);Proteomic;Traditional Chinese medicine (TCM)

期刊：

Proteome Science

ISSN：

1477-5956

年：

2022

卷：

期：

页码：

1-11

DOI：

10.1186/s12953-022-00200-7

基金类别：

This research was funded by the China Agriculture Research System of MOF and MARA (No. CARS-21), the Hunan Provincial Natural Science Foundation (China) (No. 2020JJ4466), the Hunan Provincial Health Commission Fund Project (No. 202113051021)(China) and the Administration Research Project of Hunan Traditional Chinese Medicine (China) (No. 202016)

机构署名：

本校为第一机构

院系归属：

药学院

摘要：

Every year, approximately 17 million people worldwide die due to coronary heart disease, with China ranking second in terms of the death toll. Myocardial ischemia-reperfusion injury (MIRI) significantly influences cardiac function and prognosis in cardiac surgery patients. Jiawei Danshen Decoction (JWDSD) is a traditional Chinese herbal prescription that has been used clinically for many years in China to treat MIRI. The underlying molecular mechanisms, however, remain unknown. To investigate the proteomic changes in myocardial tissue of rats g...

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TMT-based quantitative proteomics analysis of the effects of Jiawei Danshen decoction myocardial ischemia-reperfusion injury

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