Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer

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成果类型：

期刊论文

作者：

Song, Cheng;Pan, Bo;Yang, Xiao;Tang, Wei

通讯作者：

Tang, W

作者机构：

[Song, Cheng] Cent South Univ, Affiliated Canc Hosp, Hunan Canc Hosp, Dept Chinese Med,Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.

[Tang, Wei; Pan, Bo] Tradit Chinese Med Affiliated Hosp, Hunan Acad, Dept Oncol 1, 58 Lushan Rd, Changsha 410013, Hunan, Peoples R China.

[Yang, Xiao] Hunan Univ Chinese Med, Hosp 1, Dept Oncol, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Tang, W ] T

Tradit Chinese Med Affiliated Hosp, Hunan Acad, Dept Oncol 1, 58 Lushan Rd, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

antineoplastic agent;matrigel;Polyphyllin 7;Ras protein;ribonuclease A;ribonucleoside diphosphate reductase;unclassified drug;apoptosis;Article;bioinformatics;cell cycle;cell cycle assay;cell migration;cell proliferation;colon adenocarcinoma;colony formation;colorectal cancer;controlled study;down regulation;flow cytometry;gene expression;gene ontology;HCT 116 cell line;human;human cell;MAPK signaling;microarray analysis;protein protein interaction;rectum carcinoma;signal transduction;transwell assay;Western blotting;wound healing assay

期刊：

ONCOLOGY LETTERS

ISSN：

1792-1074

年：

2021

卷：

期：

页码：

1-1

DOI：

10.3892/ol.2020.12286

基金类别：

This work was supported by the Natural Science Foundation of Hunan Province (grant no. 2018JJ3312), Hunan Health Committee for Scientific Research Projects (grant no. C2019067), Academic Topics of Hunan Academy of Traditional Chinese Medicine (grant no. 201701), the Changsha Science and Technology Bureau (grant no. kq1907124) and the Department of Education of Hunan Province (grant no. 19b432).

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Colorectal cancer (CRC) is one of the most common types of human cancer. However, there is still an urgent need to identify novel treatment strategies for CRC. The present study aimed to validate the potential antitumor effects of polyphyllin VII in CRC. The present study revealed that polyphyllin VII could significantly inhibit CRC proliferation and induce cell cycle arrest and apoptosis. Moreover, the anti-metastatic effect of polyphyllin VII in CRC cells was implicated. Microarray analysis identified that polyphyllin VII could affect multipl...

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Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer

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