期刊论文

中文

中国病理生理杂志

1000-4718

2023

39

12

2176-2184

10.3969/j.issn.1000-4718.2023.12.008

No.82274526:国家自然科学基金 No.2023JJ40503:湖南省自然青年基金资助项目 No.2021SK4023:湖南省中医肿瘤临床医学研究中心 No.2021SK51410:湖南省临床医疗技术创新引导项目 No.C202203108338:湖南省卫生健康委科研重点项目 No.21B0365:湖南省教育厅优秀青年项目 No.kq2202453:长沙市自然科学基金项目

本校为第一机构

目的:基于肿瘤蛋白53(tumor protein 53,p53)/溶质载体家族7成员11(solute carrier family 7 mem-ber 11,SLC7A11/xCT)/谷胱甘肽过氧化物酶 4(glutathione peroxidase 4,GPX4)通路探讨疏肝祛瘀解毒方(SGQYJDF)诱导铁死亡抑制裸鼠肝癌增殖.方法:通过将人肝癌细胞株SK-Hep-1注射于裸鼠右腋皮下,建立异种皮下移植瘤模型,成模后分为模型对照组、SGQYJDF低、中、高剂量组和SGQYJDF中剂量联合Sorafenib组,按分组连续灌胃14 d,期间观察裸鼠肿瘤体积;灌胃14 d后,测量肿瘤质量并计算生长抑制率,采用HE染色观察各组肿瘤组织病理学变化;比色法检测各组肿瘤组织内丙二醛(malondialdehyde,MDA)、谷胱甘肽(glu...

AIM:To investigate the inhibitory effect of the"decoction for soothing liver and removing stasis and toxicity(SGQYJDF)"on hepatocellular carcinoma(HCC)proliferation in nude mice by inducing ferroptosis via the tumor protein 53(p53)/solute carrier family 7 member 11(SLC7A11/xCT)/glutathione peroxidase 4(GPX4)pathway.METHODS:An ectopic subcutaneous tumor model was established by injecting SK-Hep-1 cells subcutaneously into the right axilla of nude mice.Upon formation of tumor,the mice were randomly divided into five groups(i.e.,control group,low-...