期刊论文

Characterization and correlation analysis of lung flora in rats with silica-induced acute lung injury

中文

中国病理生理杂志

1000-4718

2024

40

1

81-88

10.3969/j.issn.1000-4718.2024.00.005

No.82374266:国家自然科学基金 No.82074250:国家自然科学基金 No.23B0342:湖南省教育厅***项目 No.S202210541126:湖南省大学生创新创业训练项目 No.2021XJJJ005:湖南中医药大学科研项目 No.2023BKS058:湖南中医药大学本科生科研创新基金资助项目

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目的:探讨二氧化硅所致急性肺损伤大鼠模型的潜在生物学机制。方法:采用随机数字表法,将SD雄性大鼠划分为正常组和二氧化硅模型组。正常组经气管灌注1 mL生理盐水,模型组经气管灌注等体积50 g/L二氧化硅混悬液。7 d后收...展开更多 目的:探讨二氧化硅所致急性肺损伤大鼠模型的潜在生物学机制。方法:采用随机数字表法,将SD雄性大鼠划分为正常组和二氧化硅模型组。正常组经气管灌注1 mL生理盐水,模型组经气管灌注等体积50 g/L二氧化硅混悬液。7 d后收集大鼠肺组织和血清,HE染色观察肺组织病理学特征,免疫组化检测肺组织核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)和消皮素D(GSDMD)蛋白表达,ELISA法...

AIM:To elucidate the possible biological mechanism of silica-induced acute lung injury in rats.METHODS:Sixteen Male Sprague-Dawley rats were divided into control and acute silicosis model groups,and instilled intratracheally with 1 mL of normal saline and 50 g/L silica ...MORE AIM:To elucidate the possible biological mechanism of silica-induced acute lung injury in rats.METHODS:Sixteen Male Sprague-Dawley rats were divided into control and acute silicosis model groups,and instilled intratracheally with 1 mL of normal saline and 50 g/L silica su...