版权说明 操作指南
首页 > 成果 > 详情

筋骨片对骨性关节炎大鼠模型的影响

认领
导出
Link by 中国知网学术期刊
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
郭建生;欧莉;周军;王小娟;郭璇
通讯作者:
Guo, J.-S.
作者机构:
College of Pharmacy, Hunan College of Traditional Chinese Medicine, Changsha 410007, China
First Hospital Attached to Hunan College of Traditional Chinese Medicine, Changsha 410007, China
[郭建生] College of Pharmacy, Hunan College of Traditional Chinese medicine, Changsha 410007, China
通讯机构:
College of Pharmacy, Hunan College of Traditional Chinese Medicine, China
语种:
中文
关键词:
筋骨片;骨性关节炎;木瓜蛋白酶;丙二醛
关键词(英文):
Jingu tablet;MDA;Osteoarthritis;Papain
期刊:
中国中药杂志
ISSN:
1001-5302
年:
2006
卷:
31
期:
3
页码:
232-235
机构署名:
本校为第一机构
院系归属:
医学院
中医学院
药学院
摘要:
目的:观察筋骨片对骨性关节炎(OA)病变发生发展及其修复作用的影响。方法:将4%的木瓜蛋白酶与0.3 mol.L-1的半胱氨酸混悬液注入大鼠膝关节进行造模,分别给予蒸馏水、阳性对照药骨刺宁胶囊以及筋骨片药液灌胃治疗。连续给药4周后处死动物,进行各项指标的测定。结果:筋骨片对模型大鼠膝关节活动范围有明显的改善作用,各剂量组与模型组比较均有显著性差异;筋骨片各剂量组对模型大鼠膝关节滑膜厚度肿胀有抑制作用,能较好缓解OA的炎性症状,对制动后膝关节内滑膜及软骨的病理变化也有显著的改善作用。筋骨片各剂量组还能明显降低滑膜组织中的丙二醛(MDA),减轻细胞损伤程度。结论:筋骨片减轻关节软...
摘要(英文):
OBJECTIVE: To observe the influence of Jingu tablet (JGT) on the development and repair of osteoarthritis (OA). METHOD: The admixture of 4% papain and 0.3 mol x L(-1) cysteine was injected into the rat's knee joint to make the model of rat OA, and distilled water, Gucining Capsule and JGT was given ig simultaneously to treat for 4 weeks in succession, and then animals were killed to measure every index. RESULT: JGT could obviously improve the scope of activities of knee joint. There were significant differences between every dosage group and model group. In every dosage group, JGT could suppre...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com