期刊论文

Wang, Y.H.

中文

中国中药杂志

1001-5302

2012

37

19

2951-2955

10.4268/cjcmm20121924

湖南省长沙市科技局重点课题（K0802103-31）；

本校为第一机构

目的:比较不同工艺所得逍遥方3种制剂（逍遥胶囊、逍遥丸、逍遥汤剂）的疏肝健脾作用。方法:强迫游泳、限制活动及隔日喂食方法制备肝郁脾虚大鼠模型,大鼠随机分为正常对照组、模型组、西沙必利组（2.7 mg.kg-1）、逍遥汤组（1.62 g.kg-1）、逍遥丸组（1.62 g.kg-1）、逍遥胶囊高、中、低剂量组（3.24,1.62,0.81 g.kg-1）,灌胃给药3周,利用高效液相色谱-电化学检测法检测其血清中NE,DA,5-HT含量;放免法测定血浆中生长抑素（SS）、胃动素（MTL）含量;免疫组化法测定组织中生长抑素（SS）、胃动素（MTL）的表达。结果:与模型组相比,逍遥汤组NE,MTL含量显著升高,5-HT和SS含量显著降低（P

OBJECTIVE: To compare the effect of three preparations of xiaoyao formula (xiaoyao capsule, xiaoyao pill and Xiaoyao decoction) on soothing liver and strengthening spleen. METHOD: The liver depression and spleen deficiency rat model were established by forcing swimming, confining movement test and feeding on alternate days. The rats were randomly divided into eight groups, namely the blank group, the model group, the Cisapride group (2.7 mg x kg(-1)), the xiaoyao decoction group (1.62 g x kg(-1)), the xiaoyao pill group (1.62 g x kg(-1)) and the Xiaoyao capsule groups of high dose (3.24 g x kg...