期刊论文

Liu, X.Y.

中文

中国中药杂志

1001-5302

2012

37

21

3233-3235

10.4268/cjcmm20122115

湖南省科技厅重点项目

本校为其他机构

目的:考察不同粒径连翘粉体中连翘苷的体外溶出规律,以指导粉碎加工技术。方法:采用HPLC测定连翘粗粉、细粉、超微粉中连翘苷的溶出量和溶出速率,并以数学模型拟合溶出曲线。结果:连翘粗粉、细粉、超微粉溶出曲线基本符合威布尔分布,其中T_(50)分别为11.8,10.5,6.8 min,Q_(45)分别为78.22%,81.91%,90.76%。结论:连翘药材经超微化后可明显提高连翘苷的溶出量和溶出速率。

Objective ： To examine the in vitro dissolution of forsythin in Forsythia suspensa powder of different particle diameter, in order to give guidance to the grinding process. Method： HPLC was used to determine the in vitro dissolution quantity and dissolution velocity of forsythin coarse powder, fine powder and ultramicroscopic powder. Result ： The dissolution curves of Forsythia suspensa coarse powder, fine powder and ultramicroscopic powder were basically inconformity to Weibull distribution. Specifically, T50 was 11.8, 10. 5 and 6. 8 min, r...