期刊论文

Zou, L.

中文

中国中药杂志

1001-5302

2012

37

16

2456-2460

10.4268/cjcmm20121623

国家自然科学基金项目（81001650）；

本校为其他机构

目的:建立麝香酮在大鼠肠灌注液中的GC-MS/MS测定方法,研究麝香酮的大鼠小肠吸收动力学特征。方法:采用GC-MS/MS测定大鼠肠循环液中的麝香酮含量;采用大鼠原位肠循环灌注法进行麝香酮吸收动力学研究。结果:麝香酮在各小肠段均有较好吸收;其吸收速度常数(K_a)和每小时吸收率(A),十二指肠>空肠(P回肠(P< 0.01)。麝香酮在小肠段的K_a, A和吸收半衰期T_(I/2)分别为0.990 h~(-1),43.58%,0.705 h。结论:麝香酮在整个肠道内均有较好吸收,十二指肠K_a,T_(1/2)优于空肠(P

Objective： To establish the method for determining muscone in rat intestinal perfusate by GC-MS/MS and study its intestinal absorption kinetic characteristics in rats. Method ： The GC-MS/MS method was used to determine the content of muscone in rat intestinal circulation fluid. In situ intestinal circulation peffusion was adopted to study absorption kinetics of muscone in rats. Result ： Muscone was proved to be well absorbed in each section of small intestine. Its absorption rate constants （ Ka ） and the absorption rate （A） in the rat in...