期刊论文

Tissue distribution of galactosyl daphnoretin liposomes in rats

中文

中国中药杂志

1001-5302

2016

41

18

3457-3462

10.4268/cjcmm20161823

湖南省“十二五”中药学重点学科建设项目（湘教通[2011]76号） 湖南省科技厅科学研究项目（2012SK3133）

本校为第一机构

研究西瑞香素半乳糖化脂质体在大鼠体内的组织分布。按剂量10 mg·kg-1给予健康SD大鼠单剂量尾静脉注射西瑞香素溶液、西瑞香素普通脂质体、西瑞香素半乳糖化脂质体,分别于给药5,15,30,45,60,120,240,360 min后采集大鼠全血和心、肝、脾、肺、肾、胃、小肠、脑、胸腺组织,采用HPLC测定血浆和各组织中西瑞香素的浓度。对比3组制剂,结果发现在不同时刻单位质量肝脏中西瑞香素的含量均以西瑞香素半乳糖化脂质体组为高;所有时间点西瑞香素半乳糖化脂质体对肝脏的靶向指数DTI值均大于西瑞香素普通脂质体,西瑞香素半乳糖化脂质体在肝组织的AUC0-6和Cm ax分别为西瑞香素溶液的2.23,5.22倍。表明西瑞香素...

To study the tissue distribution of galactosyl daphnoretin liposomes in rats. At the dose of 10 mg·kg~(-1),daphnoretin solution, daphnoretin liposomes, and galactosyl daphnoretin liposomes were administered to healthy SD rats via tail vein injection. The blood and tissue of heart, liver, spleen, lung, kidney, stomach, small intestine, brain and thymus were collected at 5, 15, 30, 45, 60, 120, 240, 360 min after administration. The concentrations of daphnoretin in plasma and tissue samples were determined by HPLC. The results showed that galact...