期刊论文

Sun, H.-F.

中文

中国中药杂志

1001-5302

2018

43

7

1310-1316

10.19540/j.cnki.cjcmm.2018.0053

黑龙江省教育厅面上项目

本校为其他机构

该文在总结芍药在心系疾病应用的文献记载和现代应用的基础上,通过中药整合药理学计算平台对其药物与疾病的作用靶点进行预测,进而阐述芍药治疗心系疾病的分子机制,为芍药后续研究提供理论依据与方法参考。古籍有载芍药具有"除血痹,破坚积,止痛,利小便,利营气"等功效,多次被用于治疗心系疾病,有些组方流传至今仍被医者青睐;随着科学发展,芍药治疗心系疾病真正发挥作用的化学成分和这些成分与机体之间的相互关系成为研究热点。为了进一步揭示芍药治疗此类疾病的药效物质基础及其分子机制,借助整合药理学平台分析得到芍药治疗心系疾病的多个靶标以及通路。其中药物和疾病的共性靶标ATP1A1与能量相...

Based on the literature review and modern application of Paeonia lactiflora in heart diseases, this article would predict the target of drug and disease by intergrative pharmacology platform of traditional Chinese medicine (TCMIP, http://www.tcmip.cn), and then explore the molecular mechanism of P. lactiflora in treatment of heart disease, providing theoretical basis and method for further studies on P. lactiflora. According to the ancient books, P. lactiflora with functions of "removing the vascular obstruction, removing the lumps, relieving p...