期刊论文

Research status of common processing technology of traditional Chinese medicine "maintaining medicinal properties after carbonisatus" and supramolecular "imprinting template" characterization technology

中文

中国中药杂志

1001-5302

2019

44

19

4293-4299

10.19540/j.cnki.cjcmm.20190522.303

国家自然科学基金项目(81573691,81803729,81703824,81874344) 湖南省自然科学基金项目(2019JJ40220,2019JJ50430).

本校为第一机构

运用中药生物超分子体特征和'印迹模板'作用规律,分析中药炮制'炒炭存性'研究现状及共性问题,并提出破解之策。根据中药炮制'炒炭存性'的历史沿革,运用生物超分子化学理论,阐明其共性问题的根源。中药为巨复生物超分子体,中药炮制就是对生物超分子体的炮制,其本质是在外界高温、高湿条件下,加辅料与不加辅料对生物超分子主客体进行化学变化的中药制药技术。中药'炒炭存性'炒的是主体分子,存的是客体分子,主客体分子的变化规律受控于'印迹模板',反映到饮片药性与药效的变化程度上。超分子化学贯穿始终,可通过超分子拓扑结构特征和印迹行为来表征炭药的'印迹模板'作用规律,并结合定量的炮制火候数...

Based on the characteristics of biological supramolecules and the law of " imprinting template", the research status and common problems in "maintaining medicinal properties after carbonisatus" in traditional Chinese medicine ( TCM) were analyzed,and the further countermeasures were put forward. According to the historical evolution of "maintaining medicinal properties after carbonisatus" in TCM processing,the origin of its common problems was clarified by using the theory of biosupramolecular chemistry. TCM is a megacomplex biological supramolecular system,so TCM processing is just the proces...