期刊论文

Mechanisms of Fuke Qianjin Capsules in treatment of pelvic inflammatory disease based on GC-MS metabolomics

Lin, L.-M.

中文

中国中药杂志

1001-5302

2019

44

22

4940-4946

10.19540/j.cnki.cjcmm.20190804.301

湖南省自然基金项目(2017JJ4045) 长沙市科技局一般项目(kq1701073) 湖南省教育厅科研项目(16C1220) 湖南省中药学一流学科项目 湖南省重大科技专项(2015TP1014).

本校为第一且通讯机构

采用金黄色葡萄球菌、大肠杆菌、β溶血链球菌等混合菌体制备盆腔炎性疾病大鼠模型,基于气相色谱-质谱（GCMS）检测技术结合PCA,PLS-DA和OPLS-DA等多元统计分析方法的代谢组学方法,分析妇科千金胶囊对大鼠血清中内源性小分子代谢物的影响。结果发现妇科千金胶囊可显著改善模型大鼠的炎症性病理特征和组织损伤;基于VIP>1和P

Pelvic inflammatory disease (PID) rat model was induced by the mixture of Escherichia coli, Staphylococcus aureus, and Streptococcus hemolytic-β. Gas chromatography-mass spectrometry (GC-MS) based metabolic profiling method was combined with multivariate statistical analysis, such as PCA, PLS-DA and OPLS-DA to analyze endogenous small molecule metabolites in serum of rats after treatment of Fuke Qianjin Capsules. The results showed that Fuke Qianjin Capsules could significantly improve the inflammatory pathological characteristics and tissue d...