期刊论文

Mechanism of Fuke Qianjin Capsules in treating intrauterine adhesion in rats through TGF-β1-PI3K/Akt signaling pathway

中文

中国中药杂志

1001-5302

2020

45

19

4705-4711

10.19540/j.cnki.cjcmm.20200514.401

国家中药标准化项目(ZYBZH-C-HUN-21) 湖南省科技重大专项(2015SK1001) 中西医结合一流学科开放基金项目(2018ZXYJH09) 湖南中医药大学研究生创新课题(2019CX23)。

本校为第一机构

从TGF-β1-PI3K/Akt信号通路探讨妇科千金胶囊对宫腔粘连(intrauterine adhesion,IUA)大鼠抗子宫内膜纤维化的作用。以雌性SD大鼠为对象,采用机械损伤+感染建立IUA大鼠模型,随机分为正常组、假手术组、戊酸雌二醇组(0.63 mg·kg~(-1)·d~(-1),B)及妇科千金胶囊高(1.008 g·kg~(-1)·d~(-1),QL-H) 、中(0.504 g·kg~(-1)·d~(-1),QJ-M) 、低(0.252 g·kg~(-1)·d~(-1), QJ-L)剂量组。药物灌胃21 d后处死大鼠,腹主动脉采血后留取子宫及肝脏,肉眼观察子宫大体形态; HE染色法观察子宫组织及肝组织病理形态学变化; Masson染色法观察子宫组织纤维化程度; ELISA法检测血清中TGF-β1,TNF-α,IL-6表达量;...

To explore the effect of Fuke Qianjin Capsules on anti-endometrial fibrosis in intrauterine adhesion (IUA) rats through TGF-β1-PI3K/Akt signaling pathway. With female SD rats as the object,IUA rat models were established through mechanical injury and infection,and they were randomly divided into normal group,sham operation group,Bujiale group (0.63 mg·kg~(-1)·d~(-1)),and high-dose Fuke Qianjin Capsules group (1.008 g·kg~(-1)·d~(-1)),medium-dose Fuke Qianjin Capsules group (0.504 g·kg~(-1)·d~(-1)),lowdose Fuke Qianjin Capsules group (0.25...