期刊论文

Research progress on potential targets-mitochondrial dynamics-related proteins in treatment of myocardial ischemia-reperfusion injury

中文

中国中药杂志

1001-5302

2020

45

17

4183-4195

10.19540/j.cnki.cjcmm.20200623.602

国家自然科学基金项目(81973753) 湖南省自然科学基金项目(2018JJ2291)。

本校为第一机构

急性心肌梗死(acute myocardial infarction,AMI)仍是世界范围内的主要致死原因。目前,AMI的处理主要是通过心肌再灌注恢复心脏供血。随着冠状动脉旁路移植术和经皮冠状动脉介入术(PCI)的广泛应用,心肌再灌注损伤是临床面临的主要问题。线粒体功能障碍是心肌缺血损伤的重要病理基础。因此,线粒体可作为抗心肌损伤的重要靶标。该文将对线粒体动力学蛋白生理功能及其在心肌缺血再灌注损伤中的病理机制、药理干预作简要综述。

Acute myocardial infarction (AMI) is still the leading cause of death worldwide.At present,the treatment of AMI is mainly to restore the cardiac blood supply through myocardial reperfusion.With the widespread use of coronary artery bypass grafting and percutaneous coronary intervention (PCI),myocardial reperfusion injury is a major clinical problem.Mitochondrial dysfunction is an important pathological basis for myocardial ischemic injury.Therefore,mitochondria can be used as an important target against myocardial damage.In this article,we would briefly review the physiological functions of mi...