期刊论文

Research progress of correlation between multidrug resistance and transporters and traditional Chinese medicine intervention

中文

中国中药杂志

1001-5302

2021

46

02

340-346

10.19540/j.cnki.cjcmm.20200602.201

国家自然科学基金项目（81874344）； 中国博士后科学基金项目（2018M640755）； 湖南省自然科学基金项目（2019JJ40220）； 湖南省中医药管理局项目（2019104）； 湖南省教育厅项目（19A366,19A382,19C1435）；

本校为第一机构

随着西药耐药性不断涌现,临床一线药物的重复给药变得更加严峻。而多药耐药（multidrug resistance,MDR）的引发因素很多,故解决问题的难度很大。近年来中药在MDR领域中不断得到应用,有关宿主机体转运蛋白关联耐药性及中药干预的研究方向已逐渐成为热点。因此,为了进一步探讨耐药性、转运蛋白和中药干预三者的相互关系,文章综述了近年来有关的研究进展,梳理现阶段此研究的成就及局限性。该文最后提出了中药干预宿主转运蛋白与胃肠道菌群影响的机体ADME的研究方向,为后续研究提供新的设想与思路。

With the emergence of drug resistance in Western medicine,the repeated administration of clinical first-line drugs becomes more severe.There are many factors leading to multidrug resistance(MDR),so it is very difficult to solve the problem.Since traditional Chinese medicine(TCM)has been used in the field of MDR in recent years,the research on the transporter-associated drug resistance and intervention of TCM has gradually become a hot spot.Therefore,in order to further explore the relationships among drug resistance,transporters,and TCM intervention,we review the relevant research progress in ...