期刊论文

Comparative analysis and research on composition of mulberry-sourced medicinal materials by fingerprint division total statistical moment method and information entropy

中文

中国中药杂志

1001-5302

2021

46

10

2547-2555

10.19540/j.cnki.cjcmm.20200924.203

国家自然科学基金项目（81903759,81874507）； 湖南省教育厅项目（18K071）； 湖南省药学一流学科开放基金项目（2018XY09）； 中药成药性与制剂制备湖南省重点实验室开放基金项目（2017）； 国家留学基金项目（201708430243）； 长沙市科学技术局项目（kq2004059）； 研究生创新课题（2018CX56）；

本校为第一机构

运用段带总量统计矩法和信息熵对桑枝、桑叶、桑白皮及桑椹4种桑源药材HPLC指纹图谱进行分析,研究桑不同入药部位化学成分及其印迹模板整体特征的差异,为寻找桑源药材"同源异效"药效物质提供基础。建立桑源药材桑枝、桑叶、桑白皮及桑椹各6批次的指纹图谱,通过计算其段带总量统计矩参数和信息熵,对桑源药材指纹图谱进行异同分析。桑源药材桑枝、桑叶、桑白皮及桑椹指纹图谱AUCT,MCRTT,VCRTT,H成对配对t检验P均小于0.05,具有显著性差异。其中,4味桑源药材均在3～11,20～24 min同时有吸收峰,说明4味桑源药材在上述相同时间段有相同或相似的化学成分,在34 min后,4味桑源药材均无吸收峰出现。4味桑源...

The present work is to analyze the HPLC fingerprints of mulberry-sourced materials (Mori Ramulus,Mori Folium,Muri Cortex,Mori Fructus) using the fingerprint division total statistical moment method and information entropy,and to study the differences of the chemical components and the overall characteristics of the imprinting template in different parts of mulberry-sourced medicinal materials,so as to provide the basis for finding the effective substances in response to " homologous and different effect" of mulberry (Morus alba). The fingerprints of 24 batches of mulberry-related materials,suc...