期刊论文

Meta-analysis of efficacy and safety of sinomenine combined with methotrexate in treatment of rheumatoid arthritis

中文

中国中药杂志

1001-5302

2021

46

01

214-224

10.19540/j.cnki.cjcmm.20200322.501

国家自然科学基金项目（81803993）； 湖南省自然科学基金项目（2017JJ3239,2018JJ3392）；

本校为第一机构

为系统评价青藤碱联合甲氨蝶呤治疗类风湿关节炎(rheumatoid arthritis,RA)有效性和安全性,该研究利用计算机全面检索万方医药期刊数据库(Wanfang)、中国期刊全文数据库(CNKI)、维普中文科技期刊全文数据库(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Cochrance Library和Web of Science等数据库建库至2020年2月4日所有关于青藤碱联合甲氨蝶呤治疗RA的研究型文献。并基于Cochrane协作网偏倚风险评价标准,运用RevMan 5.3软件对文献进行Meta分析。该研究纳入文献20篇,大多数文献具有不明确的偏倚风险。Meta分析结果显示,青藤碱联合甲氨蝶呤可显著降低DAS28评分(MD=-0.85,95%CI[-1.03,-0.6...

To systemically evaluate the efficacy and safety of sinomenine combined with methotrexate(SIN+MTX)in the treatment of rheumatoid arthritis(RA).Literature databases of Wanfang,CNKI,VIP,SinoMed,PubMed,Cochrane Library and Web of Science were retrieved comprehensively for relevant clinical trials.The literature retrieval time was from database establishment to February 4,2020.The quality of literatures was assessed by the Cochrane Evaluation Handbook 5.1.0,and qualified literature was reviewed and analyzed by using the RevMan 5.3 statistical software.Twenty randomized controlled trials met the in...