期刊论文

Research progress on anti-hyperuricemia effects and mechanisms of Chinese medicines based on regulation of intestinal flora and metabolites

中文

中国中药杂志

1001-5302

2021

46

24

6387-6394

10.19540/j.cnki.cjcmm.20210918.702

湖南省中医药科研计划项目（202023）； 长沙市自然科学基金项目（kq2007063）； 湖南省中医药研究院重点课题（201906）； 湖南创新型省份建设专项普惠性政策与创新环境建设计划项目（2020WK4003）；

本校为第一机构

高尿酸血症（hyperuricemia, HUA）是一种由于嘌呤代谢异常或尿酸排泄减少所致的代谢性疾病,以血尿酸（serum uric acid, SUA）、尿氮素（blood urea nitrogen, BUN）和肌酐（serum creatinine, SCr）水平升高等为主要临床特征,长期高尿酸血症与痛风性关节炎、糖尿病、高血压以及肾脏损伤等多种疾病的患病风险增加密切相关,因此控制血尿酸水平可能是延缓和防治高尿酸血症及合并症进程的有效措施。中医药以整体辨证论治观为基础,具有一药多效、作用靶点广泛的优势,在高尿酸血症的治疗中具有很高的应用价值;近年来,肠道微生物及代谢产物调控成为代谢性疾病领域的研究热点,随着对肠道微生物研究的不...

Chronical hyperuricemia, a severe metabolic disease characterized by increased serum uric acid, urea nitrogen, and creatinine, has a positive correlation with the risks of gouty arthritis, diabetes, hypertension, and kidney damage. Abnormal purine metabolism and reduced uric acid excretion are the major causes of hyperuricemia, which, thus, points to a potential strategy of preventing from or delaying the progress of hyperuricemia-related diseases and its complications by effectively controlling the serum uric acid level. Increasing evidence has revealed that Chinese medicines alleviate hyperu...